Clinical Research Directory

Inclusion Criteria: * Aged 18 years and older; * Willing and able to provide signed and dated consent form; * Diagnosed with head and neck squamous cell carcinoma (SCC) or a salivary gland cancer (SGC), and intends to receive external beam radiation therapy (RT) with curative intent (tumor eradication), with or without concomitant chemotherapy; OR * Diagnosed with a non-SCC, non-SGC malignancy of the head and neck region, and intends to receive RT, with or without concomitant chemotherapy. The subject must be expected to receive at least 4500 cGy to one of the following sites: 1. base of tongue 2. buccal/labial mucosa 3. epiglottis 4. floor of mouth 5. gingiva/alveolar ridge 6. hard palate 7. hypopharynx 8. larynx 9. lip 10. mandible 11. maxilla 12. maxillary sinus 13. nasal cavity 14. nasopharynx 15. neck 16. oral cavity 17. oral tongue 18. oropharynx 19. paranasal sinus/orbit 20. parotid gland 21. pharynx 22. retromolar trigone 23. soft palate 24. sublingual gland 25. submandibular gland 26. tonsil; * At least 1 natural tooth remaining or expected to remain in the mouth after completion of the pre-RT dental extractions, if any; * Willing to comply with all study procedures; * Willing to participate for the duration of the study. Exclusion Criteria: * Receiving palliative RT; * History of prior curative RT to the head and neck region to eradicate a malignancy; * Incarcerated at time of screening; * Anything that would place the subject at increased risk or preclude the subject's full compliance with or completion of the study.