Clinical Research Directory

Inclusion criteria Population 1: Community-dwelling older adults: * Community-dwelling at the time of the assessment * Ambulatory without human assistance at the time of the assessment * ADL (activity of daily living)equal to 5 or more at the time of the assessment Population 2: Older adults recovering after hip fracture surgery: * Age ≥ 65 at the time of the fracture * Minimal trauma hip fracture (Diagnosis of closed fracture of the proximal femur and no history of a fall from height higher than standing height (e.g. fall from a roof or a ladder); no history of a high impact fracture (e.g. car accident, skiing) * Unilateral hip fracture * Surgical repair of hip fracture * Surgical intervention taking place within 7 days since admission to the acute care unit. * Living in the community at the time of the fracture * Anticipated discharge back to the community * Ambulatory without human assistance prior to the fracture * ADL (activity of daily living) equal to 5 or more prior to the fracture Exclusion criteria Population 1:Community-dwelling elderly: * Diagnosis of dementia * Presence of cognitive impairment (assessed during clinical follow-up using standardized cognitive tools such as MMSE (Mini Mental Status Examination) or MOCA (Montreal Cognitive Assessment), during pre-screening period). * Inability to provide informed consent * Presence of severe or uncontrolled neurodegenerative disease like Parkinson's disease, amyotrophic lateral sclerosis or multiple sclerosis * Presence of an underlying muscle disease other than age-associated muscle waste or disuse atrophy. * History of stroke with residual hemiplegia * Diagnosis of a severe medical or psychiatric condition making the participant unlikely to understand or comply with study protocol. * Diagnosis of malignancy done in the 18 months prior the baseline visit. * Severe renal failure Population 2: Older adults recovering from hip fracture: * Pathological hip fracture * Diagnosis of dementia * Presence of cognitive impairment (assessed during clinical follow-up using standardized cognitive tools such as MMSE (Mini Mental Status Examination) or MOCA (Montreal Cognitive Assessment), during prescreening period). * Peri-operative delirium persisting after day 5 of post-operative period. * Inability to provide informed consent * Presence of severe or uncontrolled neurodegenerative disease like Parkinson's disease, amyotrophic lateral sclerosis or multiple sclerosis * Presence of an underlying muscle disease other than age-associated muscle waste or disuse atrophy. * History of stroke with residual hemiplegia * Diagnosis of a severe medical or psychiatric condition making the participant unlikely to understand or comply with study protocol. * Diagnosis of malignancy done in the 18 months prior the baseline visit. * Severe renal failure