Clinical Research Directory

Browse clinical research sites, groups, and studies.

Sites Groups Studies

Back to Studies

COMPLETED

NCT02066181

PHASE3

Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis

Sponsor: National Cancer Institute (NCI)

View on ClinicalTrials.gov

Summary

This randomized phase III trial compares the effects, good and/or bad, of sorafenib tosylate in treating patients with desmoid tumors or aggressive fibromatosis. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the proteins needed for cell growth. \[Funding Source - FDA OOPD\]

Official title: A Phase III, Double Blind, Randomized, Placebo-Controlled Trial of Sorafenib in Desmoid Tumors or Aggressive Fibromatosis (DT/DF)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

Start Date

2014-03-21

Completion Date

2022-12-01

Last Updated

2026-06-24

Healthy Volunteers

Conditions

Desmoid Fibromatosis

Interventions

OTHER

Laboratory Biomarker Analysis

Optional correlative studies

OTHER

Placebo Administration

Given PO

OTHER

Quality-of-Life Assessment

Optional ancillary studies

DRUG

Sorafenib Tosylate

Given PO

Inclusion Criteria: * Patients must have confirmation of DT/DF by local pathologist prior to registration * Patients may have been treated with locoregional therapies such as major surgery, radiation, radiofrequency ablation, or cryosurgery provided this has been completed at least 4 weeks prior to registration and recovered from therapy related toxicity to less than CTCAE grade 2 * Patients may have been treated with cytotoxic, biologic (antibody), immune or experimental therapy, tyrosine kinase inhibitors, hormone inhibitors or nonsteroidal anti-inflammatory drugs (NSAIDs) provided this has been completed at least 4 weeks prior to registration (6 weeks for mitomycin and nitrosoureas) and recovered from any therapy related toxicity to less than CTCAE grade 2 * Patients with prior or current treatment of sorafenib are excluded * No concomitant treatment, in therapeutic doses, with anticoagulants such as warfarin or warfarin-related agents, heparin, thrombin or Factor Xa inhibitors, or antiplatelet agents (e.g., clopidogrel); low dose aspirin (=\< 81 mg/day), low-dose warfarin (=\< 1 mg/day), and prophylactic low molecular weight heparin (LMWH) are permitted; please note that drugs that strongly induce or inhibit cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) or are associated with a risk of torsades are not allowed; chronic concomitant treatment of CYP3A4 inducers is not allowed (e.g., dexamethasone, phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital, and St. John's wort); as part of the enrollment/informed consent procedures, the patient will be counseled on the risk of interactions with other agents, and what to do if new medications need to be prescribed or if the patient is considering a new over-the-counter medicine or herbal product; the following drugs are strong inhibitors of CYP3A4 and are not allowed during the treatment with sorafenib: * Boceprevir * Indinavir * Nelfinavir * Lopinavir/ritonavir * Saquinavir * Telaprevir * Ritonavir * Clarithromycin * Conivaptan * Itraconazole * Ketoconazole * Mibefradil * Nefazodone * Posaconazole * Voriconazole * Telithromycin * Drugs with possible or conditional risk of torsades should be used with caution knowing that sorafenib could prolong the QT interval * Chronic daily NSAID use as treatment for controlling desmoid tumors is not allowed, and should be stopped \>= 3 days prior to registration; NSAIDS are allowed when used for desmoid tumor-related pain or for symptoms that are unrelated to desmoid disease (eg. headache, arthritis) * Patients must have measurable disease * Patients have to meet one of the following criteria to be eligible: * Disease determined unresectable or entailing unacceptably morbid surgery based on 1 or more of the following characteristics: * Multifocal disease * Disease in which there is involvement or inadequate plane from: neurovascular bundle, bone, skin, or viscera * Large size in relationship to location OR multi-compartment involvement * Progression by radiographic imaging (10% increase in size by RECIST v1.1 within 6 months of registration) * Patients with symptomatic disease which meets the following criteria Brief Pain Inventory (BPI) score greater than or equal to 3 AND one of the following: * Inability to control pain with NSAIDs and considering addition of narcotics OR * \> 30% increase in current use of narcotics OR * Addition of a new opioid narcotic * Eastern Cooperative Oncology Group (ECOG) performance status =\< 2 * Patients who are pregnant or nursing are not eligible * No patients with a history of cardiac disease: congestive heart failure \> class II New York Heart Association (NYHA); active coronary artery disease (CAD) (myocardial infarction or unstable angina within 6 months prior to study entry) * No patients with inadequately controlled hypertension (defined as a blood pressure of \>= 150 mmHg systolic and/or \>= 90 mmHg diastolic), or any prior history of hypertensive crisis or hypertensive encephalopathy * No patients with clinically significant gastrointestinal (GI) bleeding or bleeding diathesis within 30 days prior to registration * Absolute neutrophil count \>= 1,500/mm\^3 * Hemoglobin \>= 8 g/dl * Platelets \>= 75,000/mm\^3 * Total bilirubin =\< 1.5 x upper limits of normal (ULN) * Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase \[AST\])/serum glutamate pyruvate transaminase (SGPT) (aspartate aminotransferase \[ALT\]) =\< 1.5 x ULN * Calculated creatinine clearance \>= 50 mL/min using the Cockcroft-Gault equation

Locations (150)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, United States

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

PCR Oncology

Arroyo Grande, California, United States

Yale University

New Haven, Connecticut, United States

Beebe Medical Center

Lewes, Delaware, United States

Christiana Gynecologic Oncology LLC

Newark, Delaware, United States

Delaware Clinical and Laboratory Physicians PA

Newark, Delaware, United States

Helen F Graham Cancer Center

Newark, Delaware, United States

Medical Oncology Hematology Consultants PA

Newark, Delaware, United States

Christiana Care Health System-Christiana Hospital

Newark, Delaware, United States

Beebe Health Campus

Rehoboth Beach, Delaware, United States

TidalHealth Nanticoke / Allen Cancer Center

Seaford, Delaware, United States

Christiana Care Health System-Wilmington Hospital

Wilmington, Delaware, United States

MedStar Georgetown University Hospital

Washington D.C., District of Columbia, United States

MedStar Washington Hospital Center

Washington D.C., District of Columbia, United States

Sibley Memorial Hospital

Washington D.C., District of Columbia, United States

Mayo Clinic in Florida

Jacksonville, Florida, United States

John B Amos Cancer Center

Columbus, Georgia, United States

Low Country Cancer Care

Savannah, Georgia, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, United States

Hawaii Cancer Care Inc - Waterfront Plaza