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Prospective Data Collection Initiative on Colorectal Cancer
Sponsor: Dutch Colorectal Cancer Group
Summary
Survival after colorectal cancer (CRC) diagnosis strongly depends on local tumor extent, lymph node involvement and the presence of distant metastases. However, there remains great inter-patient variability regarding treatment outcome. A combination of biochemical factors, histopathological features, genomic profile, environmental factors and other clinical factors are likely to influence prognosis and treatment effect, independent from tumor stage, but it is still unclear which, how, and to what extent these factors can influence tumor recurrence and mortality in both early stage (I-III) and late stage (IV) CRC, small bowel cancer and anal cancer. Although the results from prospective clinical trials will remain the backbone of evidence based medicine, this concerns a highly selected patient population since the large majority (85%-95%) of cancer patients do not participate in clinical trials for various reasons. It is unlikely that trial participation will significantly improve in the near future. This fact has the following implications: 1) It is highly desirable to validate the results from trials in the general patient population. However, this is complicated by the fact that the documentation of patients treated in general practice (i.e. outside the scope of clinical trials) is largely insufficient to provide comparable patient cohorts in terms of prognostic characteristics and treatment parameters. 2) There is an increased availability of novel technologies that provide molecular markers with potential prognostic and/or predictive value. To test the clinical value of these markers large numbers of patients are required which greatly exceeds the number of patients who consent to participate in prospective clinical trials. 3) as a result of rapid technical developments, a range of new minimally invasive treatment options are entering the market. These interventions have the potential to be of great benefit for patients in terms of improved local control, higher probability of complete tumor removal, less damage to surrounding tissue, faster recovery and less short and long term side effects. Still, the interventions will have to prove their effectiveness, safety and superiority (or non-inferiority) to standard cancer treatments on a patient level. A prospective observational cohort study has the great opportunity to fill this gap.
Official title: Prospective Data Collection Initiative on Colorectal Cancer - a Prospective Observational Cohort Study -
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
50000
Start Date
2013-05
Completion Date
2051-01
Last Updated
2025-03-17
Healthy Volunteers
No
Conditions
Locations (67)
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, Netherlands
Noordwest Ziekenhuisgroep
Alkmaar, Netherlands
Flevoziekenhuis
Almere Stad, Netherlands
Meander Medisch Centrum
Amersfoort, Netherlands
Ziekenhuis Amstelland
Amstelveen, Netherlands
Antoni van Leeuwenhoek
Amsterdam, Netherlands
OLVG
Amsterdam, Netherlands
VUmc
Amsterdam, Netherlands
Gelre Ziekenhuizen
Apeldoorn, Netherlands
Rijnstate
Arnhem, Netherlands
Wilhelmina Ziekenhuis Assen
Assen, Netherlands
Maasziekenhuis Pantein
Beugen, Netherlands
Rode Kruis Ziekenhuis
Beverwijk, Netherlands
Amphia ziekenhuis
Breda, Netherlands
IJsselland Ziekenhuis
Capelle aan den IJssel, Netherlands
Reinier de Graaf
Delft, Netherlands
Deventer Ziekenhuizen
Deventer, Netherlands
Van Weel-Bethesda Ziekenhuis
Dirksland, Netherlands
Slingeland Ziekenhuis
Doetinchem, Netherlands
Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands
Ziekenhuis Gelderse Vallei
Ede, Netherlands
Catharina Ziekenhuis
Eindhoven, Netherlands
Maxima Medisch Centrum
Eindhoven, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
Anna Ziekenhuis
Geldrop, Netherlands
Admiraal De Ruyter Ziekenhuis
Goes, Netherlands
Rivas Beaterix Ziekenhuis
Gorinchem, Netherlands
Groene Hart Ziekenhuis
Gouda, Netherlands
Martini Ziekenhuis
Groningen, Netherlands
UMC Groningen
Groningen, Netherlands
Spaarne Gasthuis
Haarlem, Netherlands
Saxenburgh Groep
Hardenberg, Netherlands
St.Jansdal
Harderwijk, Netherlands
Frisius MC Heerenveen
Heerenveen, Netherlands
Elkerliek Ziekenhuis
Helmond, Netherlands
Ziekenhuisgroep Twente
Hengelo, Netherlands
Tergooi
Hilversum, Netherlands
Treant Zorggroep
Hoogeveen, Netherlands
Dijklander Ziekenhuis
Hoorn, Netherlands
Frisius MC Leeuwarden
Leeuwarden, Netherlands
Alrijne
Leiden, Netherlands
Leids Universitair Medisch Centrum
Leiden, Netherlands
Maastricht UMC+
Maastricht, Netherlands
MAASTRO
Maastricht, Netherlands
St. Antonius ziekenhuis
Nieuwegein, Netherlands
Canisius Wilhelmina Ziekenhuis
Nijmegen, Netherlands
Radboud UMC
Nijmegen, Netherlands
Bernhoven
Oss, Netherlands
Laurentius Ziekenhuis
Roermond, Netherlands
Bravis ziekenhuis
Roosendaal, Netherlands
Erasmus MC
Rotterdam, Netherlands
Franciscus Gasthuis & Vlietland
Rotterdam, Netherlands
Ikazia Ziekenhuis
Rotterdam, Netherlands
Maasstad Ziekenhuis
Rotterdam, Netherlands
Zuyderland Medisch Centrum
Sittard, Netherlands
Antonius Ziekenhuis
Sneek, Netherlands
ZorgSaam
Terneuzen, Netherlands
Haaglanden MC
The Hague, Netherlands
HagaZiekenhuis
The Hague, Netherlands
Ziekenhuis Rivierenland
Tiel, Netherlands
Elisabeth-TweeSteden Ziekenhuis
Tilburg, Netherlands
Diakonessenhuis
Utrecht, Netherlands
UMC Utrecht
Utrecht, Netherlands
VieCuri Medisch Centrum
Venlo, Netherlands
St. Jans Gasthuis
Weert, Netherlands
Zaans Medisch Centrum
Zaandam, Netherlands
Isala
Zwolle, Netherlands