Clinical Research Directory

Inclusion Criteria: * Type 1 diabetes treated continuously with insulin from time of diagnosis * Age 18-65 * HIV antibody negative * Normal CBC * HCG negative (females) * Anti-GAD Positive (except for subjects with c-peptide \<10pmol/L) * Fasting or stimulated c-peptide between 5-200 pmol/L * Participation in protocol #2001P001379, "Autoimmunity: In Vitro Pathogenesis and Early Detection" Exclusion Criteria: * History of chronic infectious disease such as HIV or hepatitis * History of tuberculosis, TB risk factors, positive interferon-gamma release assay (IGRA, also known as the T-SPOT.TB test), or BCG vaccination * Current treatment with glucocorticoids (other than intermittent nasal or eye steroids), or disease or condition likely to require steroid therapy * Other conditions or treatments associated with increased risk of infections such as patients with a previous history of severe burns, or treatment with immunosuppressive medications of any type (e.g. imuran, methotrexate, cyclosporine, etanercept, infliximab) for any reason * Current treatment with aspirin \> 160 mg/day or chronic, daily NSAIDs * Current treatment with antibiotics * History of keloid formation * Average HbA1c over the past 5 years (or since diagnosis if duration is less than 5 years) \<6.5 or \> 8.5% * History or evidence of chronic kidney disease (serum creatinine \> 1.5mg/dL) * History of proliferative diabetic retinopathy that has not been treated with laser therapy * History of neuropathy, foot ulcers, amputations, or kidney disease * Pregnant or not using acceptable birth control * Living with someone who is immunosuppressed and/or at high risk for infectious diseases (for example HIV+ or taking immunosuppressive medications for any reason)