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Microbiota as Potential Target for Food Allergy
Sponsor: Federico II University
Summary
Food allergy (FA) derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for enteric microflora in oral tolerance development. An altered composition of intestinal microflora results in an unbalanced local and systemic immune response to food allergens. There are qualitative and quantitative differences in gut microbiota composition in children with food allergy. These findings support the concept that specific beneficial bacteria from human intestinal microflora, designated probiotics, could restore intestinal microflora homeostasis and prevent or treat FA.
Official title: Microbiota as Potential Target for Innovative Preventive and Therapeutic Strategies for Food Allergy
Key Details
Gender
All
Age Range
6 Months - 12 Months
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2013-03
Completion Date
2020-09
Last Updated
2026-09-02
Healthy Volunteers
No
Conditions
Locations (1)
University of Naples Federico II
Naples, Naples, Italy