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Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines
Sponsor: Rutgers, The State University of New Jersey
Summary
This study will compare a local anesthetic technique that has been used to treat subjects suffering from transformed migraines (chronic migraines) versus medical management with traditional antidepressant Amitriptyline / Elavil. Subjects will be randomized into one of two treatment groups to compare the safety and efficacy of the therapies. Subjects will recieve either sphenopalatine ganglion nerve block with 5% lidocaine gel into the nasopharynx or medical management with traditional antidepressants, Elavil, to produce a reduction in the frequency and severity of the headache. We propose that there will be a difference in the outcomes when comparing the two methods of treating transformed migraines and that one research arm will result in more patient satisfaction and greater efficacy in the treatment of subjects
Official title: A Comparison of the Efficacy of 5% Lidocaine Anesthetic to Provide SPGB Vs. Elavil for the Treatment of Transformed Migraine
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2014-05
Completion Date
2020-03-16
Last Updated
2026-06-23
Healthy Volunteers
No
Interventions
SPG Block with 5% Lidocaine gel
cotten tipped applicators are with 5% lidocaine gel and placed in the nares to lye in the skin over the sphenopalitine ganglion. The applcator is use to saturate the spenopalitine ganglion with 5ml of 1% lidocaine local anesthesia
Amitriptyline
The intervention will be Amitriptyline daily (starting with 10 mg) PO for 30 Days
Locations (1)
Rutgers, Robert Wood Johnson Medical School , Pain Center of NJ
New Brunswick, New Jersey, United States