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Nitric Oxide Bioavailability and Early Life Stress (NO-Stress)
Sponsor: Augusta University
Summary
Cardiovascular disease is the leading cause of death in the United States. Other studies have shown that stress, early in life, could be a risk factor for cardiovascular disease, later in life. This study will look at the effect of early life stressors on your cardiovascular health.
Official title: Effect of Low Childhood Socioeconomic Status (SES) on Adult Endothelial Function and Nitric Oxide Bioavailability in Vivo and ex Vivo
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
74
Start Date
2014-04
Completion Date
2027-01
Last Updated
2025-01-28
Healthy Volunteers
Yes
Conditions
Interventions
Antioxidant cocktail
Flow-Mediated Dilation will be determined at baseline and 2 hours following acute antioxidant treatment
Biopsy
Under sterile conditions, a small incision (¼ - ½ inch) by the study doctor will be made and the piece of fat will be taken out. Fat tissue was chosen for this study because it is a big source of small blood vessels which we are studying
Placebo
Flow-Mediated Dilation will be determined at baseline and 2 hours following acute antioxidant treatment
NMD; 0.4mg sub-lingual nitroglycerin spray
Nitroglycerin mediated dilation will be measured immediately following an administered 0.4mg dose of nitroglycerin spray, sub-lingual.
Locations (1)
Georgia Prevention Institute , Georgia Regents University
Augusta, Georgia, United States