Clinical Research Directory

Inclusion Criteria: * Men and premenopausal women (Ages 18-50 years old) * Self-reported Black and White adults * Lean adults (BMl \<25 kg/m\^) * Obese adults (BMl \> 30 kg/m\^) Exclusion Criteria: * Having a BMI less than 16 kg/m2 (severely and very severely underweight) or that is greater than 40 kg/m2 (Class III obesity) * Having evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic disease * Having evidence of pregnancy * Using medications that affect vascular tone (i.e., nitrates, etc.) * Postmenopausal women * Uncontrolled hypertension * Individuals who are on a restricted salt diet * Having a history of chronic pain * Having a history of rheumatoid arthritis * Using medications that are contraindicated with bosentan (i.e. glyburide, cyclosporine) * Liver dysfunction (which may be identified with the blood sample we take)