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Vasoactive Drugs in Intensive Care Unit
Sponsor: University of Chicago
Summary
The investigators hypothesis is that for ICU patients with shock, the use of the vasoactive drugs phenylephrine and vasopressin will reduce tachydysrhythmias when compared to norepinephrine and epinephrine. To investigate this hypothesis, the investigators are conducting a randomized double blind controlled trial comparing phenylephrine and vasopressin vs. norepinephrine and epinephrine in ICU patients with shock that is not responsive to IV fluids. All patients admitted to the adult intensive care units at the University of Chicago will be screened for eligibility.
Official title: A Randomized Double Blind Trial of Vasoactive Drugs for the Management of Shock in the ICU
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
836
Start Date
2014-05-15
Completion Date
2026-12-01
Last Updated
2026-01-13
Healthy Volunteers
No
Conditions
Interventions
Norepinephrine
Dose range 0.03 to 0.3 mcg/kg/minute, titrated to target blood pressure.
Epinephrine
Dose range 0.03 to 0.3 mcg/kg/minute, titrated to target blood pressure.
Phenylephrine
Dose range 0.3 to 3.0 mcg/kg/minute, titrated to target blood pressure.
Vasopressin
Dose range 0.1 to 0.6 milliunits/kg/minute, titrated to target blood pressure.
Locations (1)
University of Chicago Medical Center
Chicago, Illinois, United States