Clinical Research Directory
Browse clinical research sites, groups, and studies.
Total Ankle Replacement Versus Arthrodesis Trial
Sponsor: University College, London
Summary
The purpose of TARVA is to determine whether Total Ankle Replacement (TAR) provides better clinical outcomes than ankle arthrodesis in patients aged 50-85 years with end-stage ankle osteoarthritis, and compare cost-effectiveness of the two treatments
Official title: A Randomised, Multi-centre, Non-blinded, Prospective, Parallel Group Trial of Total Ankle Replacement (TAR) Versus Ankle Arthrodesis in Patients With End Stage Ankle Osteoarthritis, Comparing Clinical Outcomes and Cost-effectiveness.
Key Details
Gender
All
Age Range
50 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
303
Start Date
2015-01
Completion Date
2029-02-28
Last Updated
2021-03-15
Healthy Volunteers
Yes
Conditions
Interventions
Total Ankle Replacement
The joints are resurfaced with metal implants and a mobile plastic liner is placed between them as the gliding surface.
Arthrodesis
The remaining damaged cartilage is removed from the ends of the bone and the two bones are then held together in compression using screws, or plates until they join to become one (bone fusion), so that there is no longer any movement at that joint.
Locations (17)
Royal Cornwall Hospitals NHS Trust
Truro, Cornwall, United Kingdom
Brighton & Sussex University Hospitals NHS Trust
Brighton, United Kingdom
North Bristol NHS Trust
Bristol, United Kingdom
Cardiff and Vale Orthopaedic Centre
Cardiff, United Kingdom
Royal Derby Hospital
Derby, United Kingdom
Royal Surrey County Hospital
Guildford, United Kingdom
Hull and East Yorkshire Hospitals NHS Trust
Hull, United Kingdom
Aintree University Hospital
Liverpool, United Kingdom
Freeman Hospital
Newcastle, United Kingdom
Northumbria Healthcare NHS Foundation Trust
Newcastle, United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust
Norwich, United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, United Kingdom
Robert Jones & Agnes Hunt Orthopaedic Hospital
Oswestry, United Kingdom
Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom
Northern General Hospital
Sheffield, United Kingdom
Royal National Orthopaedic Hospital NHS Trust
Stanmore, United Kingdom
Wrightington Hospital
Wigan, United Kingdom