Clinical Research Directory

Inclusion Criteria: * Center (Cluster Level) 1. MDR-TB Centers in KwaZulu-Natal (KZN) or Eastern Cape (EC), South Africa providing standardized 2. MDR-TB regimen according to National Department of Health guidelines 3. Facility has provided MDR-TB care for a minimum of 6 months at study initiation 4. MDR-TB Centers with facility-based access to anti-retroviral therapy 5. Facility willingness to participate in the study * Individual (Patient Level) 1. Patients 18 years of age and older, with microbiologically confirmed MDR- TB, admitted to receive inpatient care at a participating hospital who signs informed consent within 7 days of admission. 2. Patients 13 - 17 years of age, with microbiologically confirmed MDR- TB, who provide consent for study team to contact parent or legal guardian and when patient is willing and parent or legal guardian provides approval for study participation within 7 days of admission. Exclusion Criteria (Individual Patient Level): * Persons who present to the MDR-TB ward who have started MDR-TB treatment prior to admission. * Children, less than 13 years of age; only one participating center has an MDR-TB wards for children under 13. * Persons who are unable or unwilling to provide informed consent for participation * Any patient enrolled in another clinical trial that changes standard MDR- TB or HIV care.