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ACTIVE NOT RECRUITING
NCT02152631
PHASE3

A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer

Sponsor: Eli Lilly and Company

View on ClinicalTrials.gov

Summary

The main purpose of this study is to evaluate how safe and effective the study drug known as abemaciclib is in participants with lung cancer.

Official title: JUNIPER: A Randomized Phase 3 Study of Abemaciclib Plus Best Supportive Care Versus Erlotinib Plus Best Supportive Care in Patients With Stage IV NSCLC With a Detectable KRAS Mutation Who Have Progressed After Platinum-Based Chemotherapy

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

453

Start Date

2014-10-03

Completion Date

2026-12

Last Updated

2026-02-06

Healthy Volunteers

No

Interventions

DRUG

Abemaciclib

Administered orally

DRUG

Erlotinib

Administered orally

Locations (231)

Highlands Oncology Group

Fayetteville, Arkansas, United States

St. Bernards Medical Center

Jonesboro, Arkansas, United States

City of Hope National Medical Center

Duarte, California, United States

University of California - San Diego

La Jolla, California, United States

Loma Linda University School of Medicine

Loma Linda, California, United States

CBCC Global Research, Inc.

Los Angeles, California, United States

Central Coast Medical Oncology Corporation

Los Angeles, California, United States

Fort Wayne Oncology & Hematology

Los Angeles, California, United States

SMO TRIO -Translational Research

Los Angeles, California, United States

St. Joseph Heritage Medical Group

Los Angeles, California, United States

UCLA Department of Medicine-Hematology/Oncology

Los Angeles, California, United States

Cancer Care Associates Medical Group

Los Angeles, California, United States

Dignity Health Care Institute

Sacramento, California, United States

Alegent Immanuel Cancer Center

Englewood, Colorado, United States

Jewish Hospital

Englewood, Colorado, United States

Oncology Hematology West

Englewood, Colorado, United States

SMO Catholic Health Initiatives

Englewood, Colorado, United States

St Joseph Cancer Center

Englewood, Colorado, United States

St. Francis Medical Center

Englewood, Colorado, United States

Medical Oncology Hematology Consultants

Newark, Delaware, United States

Boca Raton Regional Hospital

Boca Raton, Florida, United States

Halifax Medical Center

Daytona Beach, Florida, United States

Memorial Cancer Institute

Pembroke Pines, Florida, United States

H Lee Moffitt Cancer Center

Tampa, Florida, United States

University Cancer & Blood Center, LLC

Athens, Georgia, United States

Ingalls Memorial Hospital

Harvey, Illinois, United States

Indiana University School of Medicine

Indianapolis, Indiana, United States

University of Iowa

Iowa City, Iowa, United States

Cancer Center of Kansas, P.A.

Wichita, Kansas, United States

Central Baptist Hospital

Lexington, Kentucky, United States

University of Louisville

Louisville, Kentucky, United States

Walter Reed National Military Medical Center

Bethesda, Maryland, United States

Metro-West and Greater Boston CNS Research

Framingham, Massachusetts, United States

Karmanos Cancer Institute

Detroit, Michigan, United States

Mercy Medical Research Institute

Springfield, Missouri, United States

Billings Clinic Research Center

Billings, Montana, United States

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

Broome Oncology

Johnson City, New York, United States

Weill Cornell Medical College

New York, New York, United States

Oncology Hematology Care Inc

Cincinnati, Ohio, United States

Oklahoma Cancer Specialists & Research Institute, LLC

Tulsa, Oklahoma, United States

Providence Cancer Center Oncology Hematology Care

Portland, Oregon, United States

UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, United States

Roper St. Francis Healthcare

Charleston, South Carolina, United States

Chattanooga Oncology Hematology Associates

Chattanooga, Tennessee, United States

Chattanooga Oncology Hematology Associates

Nashville, Tennessee, United States

Tennessee Oncology PLLC

Nashville, Tennessee, United States

Mary Crowley Cancer Research Center

Dallas, Texas, United States

Utah Cancer Specialists

Salt Lake City, Utah, United States

University of Vermont Medical Center

Burlington, Vermont, United States

Virginia Commonwealth University

Richmond, Virginia, United States

Kadlec Clinical Hematology & Oncology

Kennewick, Washington, United States

Swedish Medical Center

Seattle, Washington, United States

Cancer Care Northwest

Valley, Washington, United States

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Berazategui, Argentina

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Ciudad Autonoma Buenos Aires, Argentina

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Ciudad Autonoma Buenos Aires, Argentina

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Ciudad Autonoma Buenos Aires, Argentina

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Rosario, Argentina

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Rosario, Argentina

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Viedma, Argentina

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Graz, Austria

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Linz, Austria

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Linz, Austria

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Salzburg, Austria

Associação Hospital de Caridade Ijuí

Ijuí, Brazil

Hospital Bruno Born

Lajeados, Brazil

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Porto Alegre, Brazil

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Rio de Janeiro, Brazil

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Salvador, Brazil

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Sao Jose Rio Preto, Brazil

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São Paulo, Brazil

Fundação Antonio Prudente - Hospital do Câncer A.C Camargo

São Paulo, Brazil

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Calgary, Canada

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Edmonton, Canada

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Montreal, Canada

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Toronto, Canada

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Vancouver, Canada

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Winnipeg, Canada

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Beijing, China

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Beijing, China

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Beijing, China

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Changchun, China

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Changzhou, China

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Chengdu, China

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Haikou, China

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Hangzhou, China

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Hefei, China

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Nanning, China

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Shanghai, China

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Shenyang, China

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Bron, France

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Dijon, France

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Grenoble, France

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Lille, France

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Marseille, France

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Poitiers, France

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Rennes, France

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Saint-Brieuc, France

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Saint-Priest-en-Jarez, France

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Toulouse, France

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Vantoux, France

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Berlin, Germany

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Gera, Germany

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Großhansdorf, Germany

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Hamburg, Germany

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Hanover, Germany

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Heidelberg, Germany

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Immenhausen, Germany

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Nuremberg, Germany

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Regensburg, Germany

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Rosenheim, Germany

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Tübingen, Germany

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Ulm, Germany

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Athens, Greece

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Athens, Greece

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Athens, Greece

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Heraklion, Greece

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Pátrai, Greece

Soroka Medical Center

Beersheba, Israel

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Holon, Israel

Hadassah Medical Center - Ein Karem

Jerusalem, Israel

Meir Medical Center

Kfar Saba, Israel

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Petah Tikva, Israel

Sheba Medical Center

Tel Litwinsky, Israel

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Catania, Italy

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Genova, Italy

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Livorno, Italy

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Parma, Italy

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Rome, Italy

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Amagasaki, Japan

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Asahikawa, Japan

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Bunkyō City, Japan

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Bunkyō City, Japan

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Fukuoka, Japan

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Habikino, Japan

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Hirakata, Japan

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Hiroshima, Japan

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Hyōgo, Japan

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Kanazawa, Japan

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Kashiwa, Japan

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Kishiwada, Japan

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Kitaadachi-Gun, Japan

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Kobe, Japan

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Kōtoku, Japan

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Kurashiki, Japan

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Matsuyama, Japan

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Nagasaki, Japan

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Nagoya, Japan

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Nagoya, Japan

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Natori, Japan

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Okayama, Japan

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Osaka, Japan

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Osaka, Japan

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Osaka, Japan

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Sakai, Japan

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Sayama, Japan

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Sendai, Japan

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Shinjuku-ku, Japan

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Sunto-Gun, Japan

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Ube, Japan

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Utsunomiya, Japan

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Wakayama, Japan

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Yokohama, Japan

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Yonago, Japan

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Yufu-shi, Japan

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Gdansk, Poland

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Lodz, Poland

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Olsztyn, Poland

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Radom, Poland

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Szczecin, Poland

VA Caribbean Healthcare System

San Juan, Puerto Rico

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Baia Mare, Romania

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Bucharest, Romania

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Cluj-Napoca, Romania

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Cluj-Napoca, Romania

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Craiova, Romania

Arkhangelsk Regional Clinical Oncology Dispensary

Arkhangelsk, Russia

Private clinic "Evimed"

Chelyabinsk, Russia

Krasnodar regional clinical hospital # 1 n. a. S. V. Ochapovskogo

Krasnodar, Russia

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Kursk, Russia

Russian oncological scientific centre n.a. N.N. Blokhin of RAMS

Moscow, Russia

St-Petersburg scientifical practical center of specialized kinds of medical care (oncological)

Saint Petersburg, Russia

Saint-Petersburg city clinical oncology dispensary

Saint Petersburg, Russia

Republic clinical oncology dispensary of MoH of Bashkortostan Republic

Ufa, Russia

Volgograd regional clinical oncology dispensary

Volzhskiy, Russia

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Goyang-si, South Korea

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Incheon, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seowon-Gu, South Korea

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Suwon, South Korea

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Ulsan, South Korea

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A Coruña, Spain

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Barcelona, Spain

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L'Hospitalet de Llobregat, Spain

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Madrid, Spain

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Madrid, Spain

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Madrid, Spain

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Málaga, Spain

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Seville, Spain

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Valencia, Spain

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Chiayi City, Taiwan

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Kaohsiung City, Taiwan

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Kaohsiung City, Taiwan

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Taichung, Taiwan

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Taichung, Taiwan

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Tainan, Taiwan

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Taipei, Taiwan

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Taipei, Taiwan

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Taipei, Taiwan

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Zhonghe, Taiwan

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Ankara, Turkey (Türkiye)

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Ankara, Turkey (Türkiye)

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Antalya, Turkey (Türkiye)

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Edirne, Turkey (Türkiye)

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Istanbul, Turkey (Türkiye)

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Istanbul, Turkey (Türkiye)

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Istanbul, Turkey (Türkiye)

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Izmir, Turkey (Türkiye)

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Dnipropetrovsk, Ukraine

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Kharkiv, Ukraine

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Kryvyi Rih, Ukraine

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Kyiv, Ukraine

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Lutsk, Ukraine

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Poltava, Ukraine

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Sumy, Ukraine

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Uzhhorod, Ukraine

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Vinnitsa, Ukraine