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A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer
Sponsor: Eli Lilly and Company
Summary
The main purpose of this study is to evaluate how safe and effective the study drug known as abemaciclib is in participants with lung cancer.
Official title: JUNIPER: A Randomized Phase 3 Study of Abemaciclib Plus Best Supportive Care Versus Erlotinib Plus Best Supportive Care in Patients With Stage IV NSCLC With a Detectable KRAS Mutation Who Have Progressed After Platinum-Based Chemotherapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
453
Start Date
2014-10-03
Completion Date
2026-12
Last Updated
2026-02-06
Healthy Volunteers
No
Conditions
Interventions
Abemaciclib
Administered orally
Erlotinib
Administered orally
Locations (231)
Highlands Oncology Group
Fayetteville, Arkansas, United States
St. Bernards Medical Center
Jonesboro, Arkansas, United States
City of Hope National Medical Center
Duarte, California, United States
University of California - San Diego
La Jolla, California, United States
Loma Linda University School of Medicine
Loma Linda, California, United States
CBCC Global Research, Inc.
Los Angeles, California, United States
Central Coast Medical Oncology Corporation
Los Angeles, California, United States
Fort Wayne Oncology & Hematology
Los Angeles, California, United States
SMO TRIO -Translational Research
Los Angeles, California, United States
St. Joseph Heritage Medical Group
Los Angeles, California, United States
UCLA Department of Medicine-Hematology/Oncology
Los Angeles, California, United States
Cancer Care Associates Medical Group
Los Angeles, California, United States
Dignity Health Care Institute
Sacramento, California, United States
Alegent Immanuel Cancer Center
Englewood, Colorado, United States
Jewish Hospital
Englewood, Colorado, United States
Oncology Hematology West
Englewood, Colorado, United States
SMO Catholic Health Initiatives
Englewood, Colorado, United States
St Joseph Cancer Center
Englewood, Colorado, United States
St. Francis Medical Center
Englewood, Colorado, United States
Medical Oncology Hematology Consultants
Newark, Delaware, United States
Boca Raton Regional Hospital
Boca Raton, Florida, United States
Halifax Medical Center
Daytona Beach, Florida, United States
Memorial Cancer Institute
Pembroke Pines, Florida, United States
H Lee Moffitt Cancer Center
Tampa, Florida, United States
University Cancer & Blood Center, LLC
Athens, Georgia, United States
Ingalls Memorial Hospital
Harvey, Illinois, United States
Indiana University School of Medicine
Indianapolis, Indiana, United States
University of Iowa
Iowa City, Iowa, United States
Cancer Center of Kansas, P.A.
Wichita, Kansas, United States
Central Baptist Hospital
Lexington, Kentucky, United States
University of Louisville
Louisville, Kentucky, United States
Walter Reed National Military Medical Center
Bethesda, Maryland, United States
Metro-West and Greater Boston CNS Research
Framingham, Massachusetts, United States
Karmanos Cancer Institute
Detroit, Michigan, United States
Mercy Medical Research Institute
Springfield, Missouri, United States
Billings Clinic Research Center
Billings, Montana, United States
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States
Broome Oncology
Johnson City, New York, United States
Weill Cornell Medical College
New York, New York, United States
Oncology Hematology Care Inc
Cincinnati, Ohio, United States
Oklahoma Cancer Specialists & Research Institute, LLC
Tulsa, Oklahoma, United States
Providence Cancer Center Oncology Hematology Care
Portland, Oregon, United States
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States
Roper St. Francis Healthcare
Charleston, South Carolina, United States
Chattanooga Oncology Hematology Associates
Chattanooga, Tennessee, United States
Chattanooga Oncology Hematology Associates
Nashville, Tennessee, United States
Tennessee Oncology PLLC
Nashville, Tennessee, United States
Mary Crowley Cancer Research Center
Dallas, Texas, United States
Utah Cancer Specialists
Salt Lake City, Utah, United States
University of Vermont Medical Center
Burlington, Vermont, United States
Virginia Commonwealth University
Richmond, Virginia, United States
Kadlec Clinical Hematology & Oncology
Kennewick, Washington, United States
Swedish Medical Center
Seattle, Washington, United States
Cancer Care Northwest
Valley, Washington, United States
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Berazategui, Argentina
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Ciudad Autonoma Buenos Aires, Argentina
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Ciudad Autonoma Buenos Aires, Argentina
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Ciudad Autonoma Buenos Aires, Argentina
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Rosario, Argentina
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Rosario, Argentina
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Viedma, Argentina
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Graz, Austria
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Linz, Austria
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Linz, Austria
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Salzburg, Austria
Associação Hospital de Caridade Ijuí
Ijuí, Brazil
Hospital Bruno Born
Lajeados, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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Salvador, Brazil
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Sao Jose Rio Preto, Brazil
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São Paulo, Brazil
Fundação Antonio Prudente - Hospital do Câncer A.C Camargo
São Paulo, Brazil
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Calgary, Canada
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Edmonton, Canada
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Montreal, Canada
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Toronto, Canada
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Vancouver, Canada
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Winnipeg, Canada
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Beijing, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changzhou, China
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Chengdu, China
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Haikou, China
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Hangzhou, China
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Hefei, China
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Nanning, China
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Shanghai, China
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Shenyang, China
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Bron, France
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Dijon, France
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Grenoble, France
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Lille, France
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Marseille, France
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Poitiers, France
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Rennes, France
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Saint-Brieuc, France
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Saint-Priest-en-Jarez, France
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Toulouse, France
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Vantoux, France
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Berlin, Germany
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Gera, Germany
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Großhansdorf, Germany
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Hamburg, Germany
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Hanover, Germany
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Heidelberg, Germany
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Immenhausen, Germany
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Nuremberg, Germany
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Regensburg, Germany
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Rosenheim, Germany
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Tübingen, Germany
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Ulm, Germany
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Athens, Greece
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Athens, Greece
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Athens, Greece
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Heraklion, Greece
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Pátrai, Greece
Soroka Medical Center
Beersheba, Israel
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Holon, Israel
Hadassah Medical Center - Ein Karem
Jerusalem, Israel
Meir Medical Center
Kfar Saba, Israel
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Petah Tikva, Israel
Sheba Medical Center
Tel Litwinsky, Israel
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Catania, Italy
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Genova, Italy
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Livorno, Italy
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Parma, Italy
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Rome, Italy
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Amagasaki, Japan
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Asahikawa, Japan
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Bunkyō City, Japan
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Bunkyō City, Japan
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Fukuoka, Japan
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Habikino, Japan
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Hirakata, Japan
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Hiroshima, Japan
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Hyōgo, Japan
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Kanazawa, Japan
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Kashiwa, Japan
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Kishiwada, Japan
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Kitaadachi-Gun, Japan
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Kobe, Japan
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Kōtoku, Japan
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Kurashiki, Japan
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Matsuyama, Japan
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Nagasaki, Japan
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Nagoya, Japan
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Nagoya, Japan
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Natori, Japan
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Okayama, Japan
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Osaka, Japan
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Osaka, Japan
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Osaka, Japan
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Sakai, Japan
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Sayama, Japan
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Sendai, Japan
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Shinjuku-ku, Japan
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Sunto-Gun, Japan
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Ube, Japan
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Utsunomiya, Japan
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Wakayama, Japan
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Yokohama, Japan
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Yonago, Japan
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Yufu-shi, Japan
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Gdansk, Poland
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Lodz, Poland
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Olsztyn, Poland
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Radom, Poland
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Szczecin, Poland
VA Caribbean Healthcare System
San Juan, Puerto Rico
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Baia Mare, Romania
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Bucharest, Romania
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Cluj-Napoca, Romania
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Cluj-Napoca, Romania
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Craiova, Romania
Arkhangelsk Regional Clinical Oncology Dispensary
Arkhangelsk, Russia
Private clinic "Evimed"
Chelyabinsk, Russia
Krasnodar regional clinical hospital # 1 n. a. S. V. Ochapovskogo
Krasnodar, Russia
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Kursk, Russia
Russian oncological scientific centre n.a. N.N. Blokhin of RAMS
Moscow, Russia
St-Petersburg scientifical practical center of specialized kinds of medical care (oncological)
Saint Petersburg, Russia
Saint-Petersburg city clinical oncology dispensary
Saint Petersburg, Russia
Republic clinical oncology dispensary of MoH of Bashkortostan Republic
Ufa, Russia
Volgograd regional clinical oncology dispensary
Volzhskiy, Russia
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Goyang-si, South Korea
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Incheon, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seowon-Gu, South Korea
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Suwon, South Korea
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Ulsan, South Korea
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A Coruña, Spain
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Barcelona, Spain
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L'Hospitalet de Llobregat, Spain
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Madrid, Spain
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Madrid, Spain
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Madrid, Spain
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Málaga, Spain
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Seville, Spain
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Valencia, Spain
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Chiayi City, Taiwan
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Kaohsiung City, Taiwan
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Zhonghe, Taiwan
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Ankara, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Antalya, Turkey (Türkiye)
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Edirne, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Izmir, Turkey (Türkiye)
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Dnipropetrovsk, Ukraine
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Kharkiv, Ukraine
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Kryvyi Rih, Ukraine
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Kyiv, Ukraine
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Lutsk, Ukraine
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Poltava, Ukraine
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Sumy, Ukraine
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Uzhhorod, Ukraine
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Vinnitsa, Ukraine