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MRI Study of Cerebral Blood Flow in Development Disorders in Children
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The purpose of this study is reproduce the individual detection results by PET with Arterial Spin Labeling (ASL) MRI, to establish a biomarker useful in autism diagnosis.
Key Details
Gender
All
Age Range
18 Months - 18 Years
Study Type
INTERVENTIONAL
Enrollment
115
Start Date
2013-11-13
Completion Date
2023-09-13
Last Updated
2026-08-21
Healthy Volunteers
Yes
Conditions
Interventions
ASL-MRI
ASL MRI is a non-invasive technique without injection to measure rCBF at rest marking the intravascular water molecules and use it as an endogenous tracer. Premedication, if required, will concern autistic and mentally retarded subjects only.
Diffusion tensor imaging (diffusion MRI)
Diffusion MRI enables the mapping of the diffusion process of water molecules, which allows visualizing anatomical connections between different parts of the brain, noninvasively and on an individual basis. The sequence is acquired following clinical MRI sequences, while the child is still inside the MRI machine, with no further intervention applied.
Resting state MRI
This sequence is based on the synchronization of fluctuations in the blood-oxygen level dependent (BOLD) signal of different brain regions that work as a network. Therefore this sequence allows for the establishing of maps of funcitonal connectivity.
Eye-tracking
Eye tracking is a non-invasive method that allows objectifying gaze parameters during presentation of stimuli on a computer screen. Children will be presented with a series of social and no social stimuli and are required to watch it, with no further intervention applied.
Cognitive profile
Children will be asked to perform certain tasks, adapted for their age.
Locations (1)
Hôpital Necker-Enfants Malades Service de Radiologie Pédiatrique
Paris, France