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Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study)
Sponsor: University Hospital, Clermont-Ferrand
Summary
Numerous trials support the efficacy and safety of volatile anesthetic agents, namely inhalation of sevoflurane through dedicated devices, for the sedation of ICU patients. Several preclinical studies have shown that sevoflurane inhalation improves gas exchange and decreases pulmonary and systemic inflammation in experimental models of acute respiratory distress syndrome (ARDS). The purpose of our prospective monocentric, randomized, controlled trial is to evaluate the effects of an early 48-hour sevoflurane inhalation on gas exchange and inflammation in patients with ARDS.
Official title: Effect of Early 48-hour Sevoflurane Inhalation on Gas Exchange and Inflammation in Patients Presenting With Acute Respiratory Distress Syndrome (ARDS) : a Monocentric, Prospective, Randomized Study.
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2014-04
Completion Date
2016-03
Last Updated
2026-04-21
Healthy Volunteers
No
Conditions
Interventions
sevoflurane
Sedation with inhaled sevoflurane
midazolam
Sedation with intravenous midazolam
Locations (1)
CHU Clermont-Ferrand
Clermont-Ferrand, France