Clinical Research Directory

Inclusion Criteria: * Adult participants * Diagnosis of primary open angle glaucoma or normal-tension glaucoma * Never received any anti glaucoma therapy * Patients included in the group " normal pressure glaucoma " are patients where the diagnosis of optic neuropathy have been worn by the ophthalmologist with measured intraocular pressure \<21 mmHg. * Healthy controls will be examined by an ophthalmologist before inclusion Exclusion Criteria: * Anyone with a classic contraindication to MRI * Cardiovascular comorbidities or neurovascular : uncontrolled systemic hypertension , Diabetes, heart failure , carotid stenosis , ischemic stroke or transient ischemic attack. * Already treated glaucoma * Prescription by the ophthalmologist another treatment than prostaglandin analogue treatment. * Other clinical forms of glaucoma : angle closure glaucoma, neovascular glaucoma, exfoliative glaucoma, secondary glaucomas, pigment dispersion glaucoma, traumatic glaucoma, congenital glaucoma * Presence of other ocular pathology (simple refractive error allowing 10/10 of best corrected visual acuity and mild and moderate cataracts will not be considered as a criterion for non- inclusion). * History of intraocular or orbital surgery of less than 6 months .