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Reversal of Lipid-Induced Insulin Resistance
Sponsor: Yale University
Summary
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation will be assesses using a 3 hour triple tracer study (D7 glucose, 3-13C lactate and 13C4 beta-hydroxybutyrate).
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
250
Start Date
2002-10
Completion Date
2034-12
Last Updated
2025-05-16
Healthy Volunteers
Yes
Conditions
Interventions
Caloric Restriction
Dietary intervention to reduce lipid content in liver and muscle with minimal overall weight loss. Weekly visits for measurements of body weight, body composition, blood glucose and MRS measurements of liver and muscle lipid.
Locations (2)
Magnetic Resonance Research Center (MRRC)
New Haven, Connecticut, United States
Yale Center for Clinical Investigation HRU
New Haven, Connecticut, United States