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RECRUITING
NCT02193295
NA

Reversal of Lipid-Induced Insulin Resistance

Sponsor: Yale University

View on ClinicalTrials.gov

Summary

The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation will be assesses using a 3 hour triple tracer study (D7 glucose, 3-13C lactate and 13C4 beta-hydroxybutyrate).

Key Details

Gender

All

Age Range

18 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

250

Start Date

2002-10

Completion Date

2034-12

Last Updated

2025-05-16

Healthy Volunteers

Yes

Interventions

BEHAVIORAL

Caloric Restriction

Dietary intervention to reduce lipid content in liver and muscle with minimal overall weight loss. Weekly visits for measurements of body weight, body composition, blood glucose and MRS measurements of liver and muscle lipid.

Locations (2)

Magnetic Resonance Research Center (MRRC)

New Haven, Connecticut, United States

Yale Center for Clinical Investigation HRU

New Haven, Connecticut, United States