Clinical Research Directory
Browse clinical research sites, groups, and studies.
Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS)
Sponsor: Lisette Nixon
Summary
The main objectives of the PATHOS study are: To assess whether swallowing function can be improved following transoral resection of HPV-positive OPSCC, by reducing the intensity of adjuvant treatment protocols. The aim is to personalise treatment, based on disease biology (HPV status and pathology findings), to optimise patient outcomes. To demonstrate the non-inferiority of reducing the intensity of adjuvant treatment protocols in terms of overall survival in the reduced intensity treatment arms.
Official title: A Phase III Trial of Risk-stratified, Reduced Intensity Adjuvant Treatment in Patients Undergoing Transoral Surgery for Human Papillomavirus (HPV)-Positive Oropharyngeal Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1269
Start Date
2015-10
Completion Date
2028-04
Last Updated
2025-02-19
Healthy Volunteers
No
Interventions
Cisplatin
Chemotherapy
Postoperative radiotherapy
Postoperative radiotherapy (PORT)
Locations (57)
Board of Trustees of the Leland Stanford Junior University
Redwood City, California, United States
Advent Health
Orlando, Florida, United States
MD Anderson Cancer Centre
Houston, Texas, United States
Metro South Health
Brisbane, Australia
Unicancer
Paris, France
Vivantes Klinikum
Berlin, Germany
Zentrum für Hals-, Nasen- und Ohrenheilkunde
Giessen, Germany
Asklepios Kliniken
Hamburg, Germany
Kath Marienkrankenhaus gGmbH
Hamburg, Germany
Universitaetsklinikum des Saarlandes
Homburg, Germany
Universitat Leipzig
Leipzig, Germany
Ernst von Bergmann Klinikum
Potsdam, Germany
Städtisches Klinikum Solingen
Solingen, Germany
Universitätsklinikum Ulm
Ulm, Germany
University Hospitals Dorset NHS Foundation
Poole, Dorset, United Kingdom
Royal United Hospitals Bath NHS Foundation Trust
Bath, United Kingdom
Queen Elizabeth Hospital
Birmingham, United Kingdom
Royal Blackburn Hospital
Blackburn, United Kingdom
Royal Sussex County Hospital
Brighton, United Kingdom
University Hospitals Bristol NHS Foundation Trust
Bristol, United Kingdom
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
Kent and Canterbury Hospital
Canterbury, United Kingdom
HPV Research Group Section of Pathology Cardiff University ,School of Medicine
Cardiff, United Kingdom
Cardiff and Vale University Local Health Board
Cardiff, United Kingdom
Centre for Trials Research
Cardiff, United Kingdom
Velindre NHS Trust
Cardiff, United Kingdom
Castle Hill Hospital
Cottingham, United Kingdom
Derby Teaching Hospitals NHS Foundation Trust
Derby, United Kingdom
Western General Hospital
Edinburgh, United Kingdom
Royal Devon University Health Care NHS Foundation Trust
Exeter, United Kingdom
Royal Surrey County Hospital
Guildford, United Kingdom
St James University Hospital
Leeds, United Kingdom
Liverpool Head and Neck Centre
Liverpool, United Kingdom
University of Liverpool
Liverpool, United Kingdom
Cwm Taf Bro Morganwg
Llantrisant, United Kingdom
University College London Hospitals NHS Foundation Trust
London, United Kingdom
Guys and St Thomas's NHS Foundation Trust
London, United Kingdom
St Georges University Hospital
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
Central Manchester University Hospital NHS Foundation Trust
Manchester, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
The Pennine Acute Hospital Trust
Manchester, United Kingdom
The James Cook University Hospital
Middlesbrough, United Kingdom
Royal Victoria Infirmary
Newcastle upon Tyne, United Kingdom
Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
Aneurin Bevan University Health Board
Newport, United Kingdom
Northampton General Hospital
Northampton, United Kingdom
Nottingham City Hospital
Nottingham, United Kingdom
Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom
University Hospital Plymouth
Plymouth, United Kingdom
Queen Alexandra Hospital
Portsmouth, United Kingdom
Royal Preston Hospital
Preston, United Kingdom
Royal Berkshire Hospital
Reading, United Kingdom
University Hospital Southampton
Southampton, United Kingdom
Royal Stoke Hospital
Stoke, United Kingdom
City Hospitals Sunderland NHS Foundation Trust
Sunderland, United Kingdom
Swansea Bay University Local Health Board
Swansea, United Kingdom