Clinical Research Directory
Browse clinical research sites, groups, and studies.
Muscle Insulin Resistance in Aging (Mirage)
Sponsor: AdventHealth Translational Research Institute
Summary
The purpose of this study is to provide information regarding potential factors underlying metabolic dysfunction, insulin resistance, and loss of muscle mass in aging muscle.
Official title: Muscle Insulin Resistance In Aging
Key Details
Gender
All
Age Range
65 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2014-06
Completion Date
2025-12
Last Updated
2025-08-03
Healthy Volunteers
Yes
Conditions
Interventions
Exercise
Participants will complete a progressive 6-month exercise training program, 4-5 days per week, 45 min per session (180 min per week), consisting mostly of walking (both outside and on an indoor treadmill) but with the option to include stationary cycling, elliptical and rowing machines, similar to what we have utilized previously to elicit significant improvements in insulin sensitivity in both middle-age and older adults (52-55). Beginning at week 8, these subjects will also perform 2 non-consecutive resistance exercise sessions per week, 30 min per session, focused on major muscle groups using resistance machines (total days of exercise will still be 4 to 5).
Energy Restriction-Induced Weight Loss
The goal of the weight loss intervention will be to produce a weight loss of 10% body weight. A reduction of 500-1000 kcal/day - based on baseline weight -and low fat (\<30% of calories from fat) diet will be used as part of the weight loss intervention.
Locations (1)
Translational Research Institute for Metabolism and Diabetes
Orlando, Florida, United States