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Assessment of Early Changes in SD-OCT After Initiation of a Treatment by Intravitreal Aflibercept (EYLEA®)START
Sponsor: University Hospital, Bordeaux
Summary
Aflibercept (EYLEA®) induces a rapid reduction in central retinal thickness (CRT) for patients suffering from neovascular age-related-macular degeneration.1 This early dramatic reduction in CRT is already observed through week 4. Therefore it might be not necessary to consistently perform each of the three monthly consecutive intravitreal injections of the so-called loading phase.
Official title: Assessment of Early Changes in SD-OCT After Initiation of a Treatment by Intravitreal Aflibercept (EYLEA®) (2mg) Over a 12-week Period for Patients Suffering From Neovascular Age-related Macular Degeneration (AMD) French SD OCT in wAMD
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2014-09
Completion Date
2015-06
Last Updated
2026-09-17
Healthy Volunteers
No
Interventions
Intravitreal injection
2 mg intravitreal Aflibercept initiated with one injection every 4 weeks for three consecutive doses (loading dose) The duration of the follow-up is 12 weeks. This means 3 injections per patient should be given over the study period
Locations (10)
Service d'ophtalmologie Hôpital Henri Mondor 40, avenue de Verdun
Créteil, France
Service Ophtalmologie CHU DIJON 14 rue Gaffarel BP 77908
Dijon, France
Service d'Ophtalmologie Hôpital de la croix rousse
Lyon, France
Cabinet d'ophtalmologie 1 rue Pougin de la Maisonneuve
Montargis, France
Sce Ophtalmologie CHU Nantes 1 place Alexis Ricordeau
Nantes, France
Centre ophtalmique d'imagerie et de laser (CIL) 11 rue Antoine Bourdelle
Paris, France
Sce du Pr SAHEL Fondation ROTHSCHILD 25 rue Manin
Paris, France
Sce Ophtalmologie Hôpital Lariboisière 2 rue Ambroise Paré
Paris, France
Service Opthalmo 2 Clinique Mathilde 4 rue de Lessard
Rouen, France
Centre Ophtalmologie Transparence 30 Boulevard Heurteloup
Tours, France