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Curcumin Associated With Thiopurin in the Prevention of Post-op Recurrence in Crohn Disease
Sponsor: University Hospital, Clermont-Ferrand
Summary
Curcumin, the active ingredient of turmeric, has been used for long term in the treatment of inflammatory conditions. Inhibition of NF-κB is postulated as the main mechanism responsible for the anti-inflammatory effect of curcumin Aim : to study the effect of curcumin, 3g per day, as compared to placebo, combined with thiopurines in the prevention of Crohn's disease post-operative recurrence.
Official title: Controlled, Randomized, Double Blind Study, Comparing Curcumin to Thiopurines in the Prevention of Post-op Recurrence in Crohn Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
61
Start Date
2014-12
Completion Date
2018-06
Last Updated
2026-05-20
Healthy Volunteers
No
Conditions
Interventions
Curcumin
subjects will be randomized into two arms; they will be given either placebo or curcumin 3g/d per os plus thiopurines during 6 months in a double-blind manner. Rutggerts endoscopic score at 6 months will be the main judgment criteria
Locations (1)
CHU de Clermont-Ferrand
Clermont-Ferrand, France