Clinical Research Directory

Inclusion Criteria: * Patient 18-75 years of age, inclusive * Patient qualifies for primary total knee arthroplasty based on physical exam and medical history, including diagnosis of severe knee pain and disability due to at least one of the following: a) rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis; b) collagen disorders and/or avascular necrosis of the femoral condyle; c) post-traumatic loss of joint configuration, particularly when there is patellofemoral erosion, dysfunction or prior patellectomy; d) moderate valgus, varus, or flexion deformities; or e) the salvage of previously failed surgical attempts that did not include partial or total knee arthroplasty of the ipsilateral knee * Patient has participated in a study-related Informed Consent process * Patient is willing and able to provide written Informed Consent by signing and dating the IRB or EC approved Informed Consent Form * Patient is willing and able to complete scheduled study procedures and follow-up evaluations * Independent of study participation, patient is a candidate for commercially available Persona fixed bearing knee components implanted in accordance with product labeling Exclusion Criteria: * Patient is currently participating in any other surgical intervention studies or pain management studies * Previous history of infection in the affected joint and/or other local/systemic infection that may affect the prosthetic joint * Insufficient bone stock on femoral or tibial surfaces * Skeletal immaturity * Neuropathic arthropathy * Osteoporosis or any loss of musculature or neuromuscular disease that compromises the affected limb * Stable, painless arthrodesis in a satisfactory functional position * Severe instability secondary to the absence of collateral ligament integrity * Rheumatoid arthritis accompanied by an ulcer of the skin or a history of recurrent breakdown of the skin * Patient has a known or suspected sensitivity or allergy to one or more of the implant materials * Patient is pregnant or considered a member of a protected population (e.g., prisoner, mentally incompetent, etc.) * Patient has previously received partial or total knee arthroplasty for the ipsilateral knee