Clinical Research Directory

Inclusion Criteria: a subject must meet all of the following criteria: * high risk (according to ductch national criteria) for gestational diabetes * aged between 18 and 40 years * gestational age between 8 and 12 weeks * and able to communicate and read in Dutch. Exclusion Criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: * no singleton pregnancy judged by ultrasonography * diagnosis of diabetes mellitus before the current pregnancy- * high fasting glucose at first trimester (\> 5.3 mmol/l) * cardiac insufficiency-\\ * renal insufficiency (MDRD \< 60) * liver disease * use of medication other than Paracetamol or vitamins and incompetent women.