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Summary
All patients with recurrent colorectal cancer in the pelvis are eligible. The original primary tumour staging scans and resected surgical specimen needs to be available. Patients' recurrence will be staged using our proposed MRI classification. We will be assessing the original primary staging scans and histopathology to learn about risk factors for recurrence. We will record treatment for the recurrence, and patients will be followed up for three years.
Official title: Investigating the Origins of Pelvic Recurrence in Colorectal Cancer
Key Details
Gender
All
Age Range
16 Years - Any
Study Type
INTERVENTIONAL
Enrollment
383
Start Date
2014-09-25
Completion Date
2031-12
Last Updated
2024-10-17
Healthy Volunteers
No
Conditions
Interventions
New Radiological Staging Classification system for patients with advanced and recurrent colorectal cancer undergoing pelvic exenterative surgery
Currently there are no validated criteria or guidelines for judging whether advanced primary or recurrent colorectal cancer can be successfully removed and for selecting which patients should undergo this form of more radical surgery as is exenterative surgery. We are proposing that by validating the detailed evaluation of imaging of the tumour distribution within the pelvis using a new radiological staging classification, this will enable clear selection criteria to be established and will improve surgical planning.
Locations (4)
Oslo University Hospital
Oslo, Norway
St Mark's Hospital
Harrow, London, United Kingdom
Churchill Hospital
Oxford, Oxfordshire, United Kingdom
Royal Marsden Hospital NHS Foundation Trust
Sutton, United Kingdom