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Omega 3 Fatty Acids and ERPR(-)HER2(+/-) Breast Cancer Prevention
Sponsor: City of Hope Medical Center
Summary
The study aims to determine biological changes associated with a low vs high dose of omega 3 fatty acids, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), over 12 months in women at risk for recurrent breast cancer. The objectives of the trial are to develop mammary epithelial, adipose tissue specific markers of exposure and response to omega 3 fatty acid supplements that can be carried forward into definitive intervention trials of omega 3 fatty acids for breast cancer prevention. The investigators will randomize 80 subjects with hormone receptor negative, HER-2/neu overexpression positive or negative breast cancer to either a high or low dose of omega 3 fatty acids. Using fine needle aspiration to procure cellular samples of breast epithelial and adipose tissue, the investigators will determine the effects of omega 3 fatty acids on mammary specific biomarkers of response.
Official title: Omega-3 Fatty Acids and ERPR(-) and HER-2/Neu(+/-) Breast Cancer Prevention
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2017-08-09
Completion Date
2027-02-05
Last Updated
2026-04-03
Healthy Volunteers
No
Conditions
Interventions
omega 3 fatty acids
supplied as soft gelatin capsules for oral administration
Locations (2)
City of Hope Medical Center
Duarte, California, United States
The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States