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ACTIVE NOT RECRUITING
NCT02295059
NA

Omega 3 Fatty Acids and ERPR(-)HER2(+/-) Breast Cancer Prevention

Sponsor: City of Hope Medical Center

View on ClinicalTrials.gov

Summary

The study aims to determine biological changes associated with a low vs high dose of omega 3 fatty acids, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), over 12 months in women at risk for recurrent breast cancer. The objectives of the trial are to develop mammary epithelial, adipose tissue specific markers of exposure and response to omega 3 fatty acid supplements that can be carried forward into definitive intervention trials of omega 3 fatty acids for breast cancer prevention. The investigators will randomize 80 subjects with hormone receptor negative, HER-2/neu overexpression positive or negative breast cancer to either a high or low dose of omega 3 fatty acids. Using fine needle aspiration to procure cellular samples of breast epithelial and adipose tissue, the investigators will determine the effects of omega 3 fatty acids on mammary specific biomarkers of response.

Official title: Omega-3 Fatty Acids and ERPR(-) and HER-2/Neu(+/-) Breast Cancer Prevention

Key Details

Gender

FEMALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

80

Start Date

2017-08-09

Completion Date

2027-02-05

Last Updated

2026-04-03

Healthy Volunteers

No

Conditions

Interventions

DIETARY_SUPPLEMENT

omega 3 fatty acids

supplied as soft gelatin capsules for oral administration

Locations (2)

City of Hope Medical Center

Duarte, California, United States

The Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States