Clinical Research Directory

Inclusion Criteria: For healthy volunteers: 1. 20 ≤ BMI ≤ 25 2. Age 18-60 3. Right handed 4. Stable body weight for at least 3 consecutive months at start of study and no history of behavioural, therapeutic or surgical treatment aiming at or leading to weight loss/gain For obese subjects: 1. BMI \> 30 2. Age 18-60 3. Right handed 4. Stable body weight for at least 3 consecutive months at start of the study and no behavioural, therapeutic or surgical treatment aiming at or leading to weight loss/gain for at least 3 consecutive months For FD patients: 1. FD diagnosis according to 'Rome III' criteria 2. Age 18-60 3. Right handed 4. 5% weight loss since onset of symptoms Exclusion Criteria: 1. Medical conditions (current or history): * Abdominal/thoracic surgery except appendectomy * Gastrointestinal, endocrine (especially diabetes), or neurological diseases * Cardiovascular, respiratory, renal or urinary diseases * Hypertension * Food or drug allergies * Head trauma with loss of consciousness 2. Psychiatric disorders: * Eating disorders * Psychotic disorders * Major depressive disorder * Somatoform disorder 3. Medication use: * No history of cannabis use or any other drug of abuse for at least 12 months prior to the study * All medication except oral contraception; 4. Known allergy to dronabinol and/or sesam oil 5. Pregnancy, plans to conceive or refusal to take adequate precaution to avoid pregnancy 6. Subjects who refuse to abstain from driving during the study