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Non-endoscopic EC Screening Program in Northern Iran
Sponsor: Tehran University of Medical Sciences
Summary
The aim of this study is to assess the effects of implementation of a non-endoscopic esophageal cancer-screening program on outcomes of interest in an asymptomatic high-risk population in Golestan Province, Iran. Study population will be recruited in two arms. In the intervention arm, cytological examination of the esophagus will be performed using a capsule sponge device. Subjects in the control arm will receive no intervention. All participants will be followed for 5 years. The outcomes of interest, including the incidence of esophageal cancer as well as mortality rates, will be compared between the two groups.
Official title: Non-endoscopic Esophageal Cancer Screening Program in Northern Iran
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
12000
Start Date
2016-12
Completion Date
2030-12
Last Updated
2026-10-16
Healthy Volunteers
Yes
Conditions
Interventions
Capsule sponge
Capsule sponge cytology examination coupled with H\&E staining analysed for the presence of atypia and p53 immunohistochemistry