Clinical Research Directory

Inclusion Criteria: * Diagnosis of SLE according to revised criteria of American College of Rheumatology * Being affiliated to health insurance * Having signed an informed consent (later than the day of inclusion and before any examination required by research) Exclusion Criteria: * \> 20mg/day of prednisone equivalent for \> 7 days 30 days before the pre-inclusion. * Diseases flare 3 months before the inclusion. A disease flare is defined by an increase of SLEDAI score \>3 and or a change of the immunosuppressive treatment and or an increase of steroids dose. * Is treated or has received 3 months before the pre-inclusion steroids pulses or intravenous immunoglobulins. * Renal involvement that could required a kidney biopsy. * Required surgery in the next 12 weeks. * Has been treated by cyclophosphamide 3 months before the pre-inclusion. * Has been treated by biotherapy 6 months before the pre-inclusion. * Contraindication to clopidogrel (annex 1). * History of cancer except healed basal cell carcinoma. * History of severe hemorrhage * Disease exposing to hemorrhage * Associated antiphospholipid syndrome * Pregnant or breastfeeding women * No contraception for women of childbearing age * Severe hypertension * Ongoing statin, non-steroidal anti-inflammatory, antiplatelet and anticoagulant drugs. * Being under guardianship * Patient participating at an other biomedical research with an exclusion period at the screening visit.