Clinical Research Directory

Inclusion Criteria: 1. Patients undergoing aortic valve replacement (+/- coronary bypass AND/OR mitral valve surgery) according to clinical indications (ESC guidelines for the management of valvular heart disease) 2. Age ≥18 years 3. No indication for long term anticoagulation at the time of enrollment. 4. Patients with CHADS-VASC score ≥2 5. Patient is willing to comply with specified follow-up evaluations 6. Patient or legally authorized representative has been informed of the nature of the study, agrees to its provisions and has been provided written informed consent, approved by the appropriate Medical Ethics committee or Institutional Review Board. Exclusion Criteria: * Age \< 18 years * Expected survival \< 1 year * Chronic atrial fibrillation * Indication for long term anticoagulation therapy before the index procedure * Mechanical valve implantation previously or at the index procedure * Any significant medical condition, which in the Investigator's opinion may interfere with the patient's optimal participation in the study.