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Phenotype, Genotype & Biomarkers in ALS and Related Disorders
Sponsor: University of Miami
Summary
The goals of this study are: (1) to better understand the relationship between the phenotype and genotype of amyotrophic lateral sclerosis (ALS) and related diseases, including primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA), and frontotemporal dementia (FTD); and (2) to develop biomarkers that might be useful in aiding therapy development for this group of disorders.
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
700
Start Date
2015-04
Completion Date
2026-08
Last Updated
2025-07-03
Healthy Volunteers
Yes
Conditions
Locations (15)
Stanford University
Palo Alto, California, United States
University of California San Diego (UCSD)
San Diego, California, United States
California Pacific Medical Center (CPMC)
San Francisco, California, United States
University of Miami
Miami, Florida, United States
University of Iowa
Iowa City, Iowa, United States
Kansas University Medical Center (KUMC)
Kansas City, Kansas, United States
Twin Cities ALS Research Consortium
Minneapolis, Minnesota, United States
Wake Forest University
Winston-Salem, North Carolina, United States
Cleveland Clinic
Cleveland, Ohio, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
University of Texas Southwestern (UTSW)
Dallas, Texas, United States
University of Texas Health Science Center San Antonio (UTHSCSA)
San Antonio, Texas, United States
University of Virginia (UVA)
Charlottesville, Virginia, United States
Eberhard Karls University of Tübingen
Tübingen, Germany
University of Cape Town
Cape Town, South Africa