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ACTIVE NOT RECRUITING
NCT02330042

OCT Biomarkers for Diabetic Retinopathy

Sponsor: Oregon Health and Science University

View on ClinicalTrials.gov

Summary

Diabetic retinopathy (DR) is caused by changes in the blood vessels of the retina associated with long-term Type 1 or Type 2 diabetes mellitus. DR is a leading cause of blindness in the United States. Standard optical coherence tomography (OCT) cannot directly detect vascular changes, which may occur early affecting the passage of blood through the tiny capillaries (reduced capillary flow) or cause the greatest damage through formation of abnormal blood vessel growth (neovascularization). Currently, fluorescein angiography (FA) is the gold standard for detecting these changes, but FA requires an injection of a dye into the vein of the arm of the patient. This dye can cause undesirable side effects. Recently, OCT has been used to make functional measurements (such as total retinal blood flow among others) and to perform angiography. Thus, functional OCT may provide a useful, alternate way to evaluate diabetic retinopathy.

Official title: Functional Optical Coherence Tomography-Derived Biomarkers for Diabetic Retinopathy

Key Details

Gender

All

Age Range

18 Years - 79 Years

Study Type

OBSERVATIONAL

Enrollment

165

Start Date

2015-01-26

Completion Date

2026-12

Last Updated

2025-09-09

Healthy Volunteers

Yes

Locations (1)

Oregon Health & Science University

Portland, Oregon, United States