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OCT Biomarkers for Diabetic Retinopathy
Sponsor: Oregon Health and Science University
Summary
Diabetic retinopathy (DR) is caused by changes in the blood vessels of the retina associated with long-term Type 1 or Type 2 diabetes mellitus. DR is a leading cause of blindness in the United States. Standard optical coherence tomography (OCT) cannot directly detect vascular changes, which may occur early affecting the passage of blood through the tiny capillaries (reduced capillary flow) or cause the greatest damage through formation of abnormal blood vessel growth (neovascularization). Currently, fluorescein angiography (FA) is the gold standard for detecting these changes, but FA requires an injection of a dye into the vein of the arm of the patient. This dye can cause undesirable side effects. Recently, OCT has been used to make functional measurements (such as total retinal blood flow among others) and to perform angiography. Thus, functional OCT may provide a useful, alternate way to evaluate diabetic retinopathy.
Official title: Functional Optical Coherence Tomography-Derived Biomarkers for Diabetic Retinopathy
Key Details
Gender
All
Age Range
18 Years - 79 Years
Study Type
OBSERVATIONAL
Enrollment
165
Start Date
2015-01-26
Completion Date
2026-12
Last Updated
2025-09-09
Healthy Volunteers
Yes
Conditions
Locations (1)
Oregon Health & Science University
Portland, Oregon, United States