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NCT02334956

Linking fMRI to Mobile Technologies in Addiction Research: Pathophysiology of Executive Deficits, Craving and Substance Use

Sponsor: University Hospital, Bordeaux

View on ClinicalTrials.gov

Summary

120 individuals with alcohol, cannabis or nicotine dependence as well as healthy controls will be administered a whole-brain imaging exam. The current research project constitutes a highly novel approach to understanding the pathophysiology of addiction through its combination of neuroimaging with state-of-the-art information concerning the real-time expression of risk factors.

Key Details

Gender

All

Age Range

18 Years - 64 Years

Study Type

INTERVENTIONAL

Enrollment

107

Start Date

2015-03

Completion Date

2018-01-10

Last Updated

2026-06-01

Healthy Volunteers

Yes

Conditions

Addiction

Interventions

OTHER

Brain MRI

Inclusion Criteria: * Inclusion criteria patient: * Aged 18-64 years * Being affiliated to health insurance * Having signed an informed consent (later than the day of inclusion and before any examination required by research) * Participation in the study MOBICOG for patients with addiction * Fulfils diagnostic criteria for one of the following groups: Group A: Patients with current (last 12 months) Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) substance addiction (Alcohol / Cannabis / Nicotine); initiation of treatment for addiction within 30 days preceding enrollment in the study; absence of other axis 1 psychiatric disorder currently being treated (by psychotherapy or pharmacotherapy); absence of current or lifetime bipolar disorder or schizophrenia. Group AM: Patients with current (last 12 months) DSM-IV substance addiction (Alcohol / Cannabis / Nicotine); initiation of treatment for addiction within 30 days preceding enrollment in the study; presence of currently treated unipolar mood disorder (by psychotherapy or pharmacotherapy); absence of current or lifetime bipolar disorder or schizophrenia. Group AS: Patients currently treated for DSM-IV schizophrenia (last 12 months) with DSM-IV substance addiction (Alcohol / Cannabis / Nicotine); absence of other axis 1 psychiatric disorder currently being treated (by psychotherapy or pharmacotherapy); absence of current or lifetime bipolar disorder. Inclusion criteria healthy volunteers: * Aged 18-64 years * Participation in the study MOBICOG * Being affiliated to health insurance * Having signed an informed consent (later than the day of inclusion and before any examination required by research) * Healthy volunteers without current addiction and with no other currently-treated axis 1 DSM-IV disorder (by psychotherapy or pharmacotherapy); absence of current or lifetime bipolar disorder or schizophrenia Exclusion Criteria: * Presence of a counter-indication for MRI * Presence of any health problem preventing travel to the imaging service of the University Hospital * Being unable to provide consent to participate * Pregnant or breastfeeding woman

Locations (2)

CHU de Bordeaux

Bordeaux, France

Hôpital Charles Perrens