Clinical Research Directory

Inclusion Criteria: * Men and women age 18-75; * Diagnosis of current gambling disorder based on DSM-5 criteria and confirmed using the clinician-administered Structured Clinical Interview for Pathological Gambling (SCI-PG) (12); * Gambling behavior within 2 weeks prior to enrollment; * Women of child bearing age are required to have a negative result on a beta-human chorionic gonadotropin pregnancy test; * Women of childbearing potential utilizing a medically accepted form of contraception defined as double barrier, oral contraceptive, injectable contraceptive, implantable contraceptive devices, and abstinence Exclusion Criteria: * Infrequent gambling (i.e. less than one time per week) that does not meet DSM-5 criteria for gambling disorder; * Unstable medical illness or clinically significant abnormalities on laboratory tests, EKG, or physical examination at screen as determined by the investigator; * History of seizures; * Myocardial infarction within 6 months; * Current pregnancy or lactation, or inadequate contraception in women of childbearing potential; * A need for medication other than milk thistle with possible psychotropic effects or unfavorable interactions as determined by the investigator; * Clinically significant suicidality (defined by the Columbia Suicidal Scale); * Lifetime history of bipolar disorder type I or II, schizophrenia, or any psychotic disorder; * Initiation of psychotherapy or behavior therapy within 3 months prior to study baseline; * Previous treatment with milk thistle