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ACTIVE NOT RECRUITING

NCT02338310

PHASE3

Trial of Perioperative Endocrine Therapy - Individualising Care

Sponsor: Institute of Cancer Research, United Kingdom

View on ClinicalTrials.gov

Summary

To determine whether perioperative endocrine therapy with an aromatase inhibitor (AI) followed by standard adjuvant therapy improves outcome compared with standard adjuvant therapy alone in postmenopausal women with hormone receptor positive breast cancer. To determine whether the proliferation marker Ki67 as measured by immunohistochemistry (IHC) in the excised cancer around 2 weeks after starting AI therapy will predict for time to recurrence (TTR) in the individual patient more effectively than the pre-treatment Ki67 value. To determine whether molecular profiling 2 weeks after starting endocrine therapy predicts for long-term outcome in postmenopausal women with hormone receptor positive breast cancer better than at diagnosis.

Key Details

Gender

FEMALE

Age Range

50 Years - Any

Study Type

INTERVENTIONAL

Enrollment

4486

Start Date

2008-09

Completion Date

2034-04

Last Updated

2020-02-17

Healthy Volunteers

Conditions

Breast Cancer

Interventions

DRUG

Aromatase Inhibitors

Choice of AI is according to centre policy; any brand can be used

Inclusion Criteria: 1. Post menopausal women with core biopsy-proven hormone receptor positive invasive breast cancer. Postmenopausal is defined as a woman aged ≥50 years fulfilling any one of the following criteria: i) with amenorrhoea \>12 months and an intact uterus; ii) has undergone a bilateral oophorectomy; iii) in women who have undergone a hysterectomy, then FSH levels within the postmenopausal range (utilising ranges from the testing laboratory facility) are required if the patient is aged \<55 years; or iv) in women who have been on HRT within the last 12 months and therefore not amenorrhoeic, FSH levels within the postmenopausal range (utilising ranges from the testing laboratory facility) are required if the patient is aged \<55 years. 2. No evidence of metastatic spread by standard assessment according to local guidelines 3. Standard adjuvant endocrine therapy indicated 4. A palpable tumour of any size , or a tumour with an ultrasound size of at least 1.5cm 5. WHO performance status of 0 or 1 6. Written informed consent to participate in the trial and to donation of tissue (fresh tissue and surplus tissue from diagnostic procedures) and blood samples. Exclusion Criteria: 1. Locally advanced/inoperable breast cancer 2. Evidence of metastatic disease 3. Previous invasive breast cancer (surgically treated DCIS or LCIS allowed) 4. Current bilateral breast cancer 5. Multiple unilateral tumours with different ER/PgR/HER2 status, grade or type (e.g. ductal vs lobular) i.e. anything that suggests two or more different cancers. Multifocal disease with homogenous ER/PgR/HER2 status, grade and type is allowed if at least one lesion is palpable or at least 1.5cm on ultrasound; the largest lesion should be used for sample collection and CRF completion. 6. Concurrent use (defined as use within 4 weeks prior to diagnostic tissue sample being taken) of HRT or any other oestrogen-containing medication (including vaginal oestrogens) 7. Previous use of oestrogen implants at ANY time 8. Prior endocrine therapy or chemotherapy for breast cancer 9. Any invasive malignancy diagnosed within previous 5 years (other than basal cell carcinoma or cervical carcinoma in situ) 10. Any severe co-incident medical disease, inability to give informed consent or unavailability for follow-up 11. Treatment with an unlicensed or investigational drug within 4 weeks before randomisation 12. Current, continuous, long term systemic steroid usage

Locations (128)

Ulster Hospital

Dundonald, Belfast, United Kingdom

Heatherwood and Wexham Park Hospitals NHS trust

Slough, Berkshire, United Kingdom

Stoke Mandeville Hospital

Aylesbury, Buckinghamshire, United Kingdom

Prince Philip Hospital

Llanelli, Carmarthenshire, United Kingdom

Craigavon Area Hospital

Portadown, Co.Amagh, United Kingdom

Wansbeck General Hospital

Ashington, England, United Kingdom

North Devon District Hospital

Barnstaple, England, United Kingdom

City Hospital - Birmingham

Birmingham, England, United Kingdom

Royal Blackburn Hospital

Blackburn, England, United Kingdom

Pilgrim Hospital

Boston, England, United Kingdom

Bradford Teaching Hospitals NHS Trust, St Luke's Hospital

Bradford, England, United Kingdom

Burnley General Hospital

Burnley, England, United Kingdom

Cumberland Infirmary

Carlisle, England, United Kingdom

Chelmsford and Essex Centre

Chelmsford, England, United Kingdom

Countess of Chester Hospital

Chester, England, United Kingdom

Chesterfield Royal Hospital

Chesterfield, England, United Kingdom

Essex County Hospital

Colchester, England, United Kingdom

Doncaster Royal Infirmary

Doncaster, England, United Kingdom

Russells Hall Hospital

Dudley, England, United Kingdom

Wycombe General Hospital

High Wycombe, England, United Kingdom

Airedale General Hospital

Keighley, England, United Kingdom

Kidderminster Hospital

Kidderminster, England, United Kingdom

Whittington Hospital