Clinical Research Directory

Inclusion Criteria: * Stroke \> 3 months prior * Completion of all regular post-stroke physical therapy * Adequate language and neurocognitive function to participate in testing and training and to provide informed consent * Able to walk 10 meters without human assistance Exclusion Criteria: * Regular structured resistive exercise (\>2x/week) * Alcohol consumption \>3oz. liquor, 3 x 4oz. glasses of wine, or 3 x 12oz beers/day, by self report * Neurological history of: a) dementia by clinical evaluation, b) severe receptive or global aphasia, which confounds testing and training, operationally defined as unable to follow 2 point commands, c) untreated major depression by clinical interview * Medical History: a) recent hospitalization (less than 3 months prior to study entry) for severe medical disease, b) orthopedic or chronic pain condition restricting exercise, c) pulmonary or renal failure, d) active cancer, e) untreated poorly controlled hypertension measured on at least 2 occasions (greater than 190/100) f) untreated and / or poorly controlled diabetes with fasting blood glucose of greater than 170 and HbA1c greater than 10.0, g) medications: oral steroids, h) currently pregnant * Cardiac history of: a) unstable angina, b) recent (less than 3 months prior to study entry) myocardial infarction, congestive heart failure (NYHA category II-IV); c) hemodynamically significant valvular dysfunction * Any medical condition that, in the opinion of the Investigator, might interfere with the subject's participation in the study, poses any added risk for the subject, or confounds the assessment of the subject