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Efficacy of Local Anesthesic on Diaphragmatic Function After Upper Abdominal Surgery
Sponsor: University Hospital, Rouen
Summary
Upper abdominal surgery is known to induce such pulmonary complications as pneumonia, atelectasis, pleural effusion. The post operative diaphragmatic dysfunction participates to these complications and lasts for 7 days after upper abdominal surgery. The sniff-test is a recognized tool for measuring the diaphragmatic function.The purpose of this study is to evaluate the effectiveness of parietal analgesia with continuous infiltration of local anesthesic on diaphragmatic function after upper abdominal surgery through a subcostal incision. Our main outcome is to measure the diaphragmatic function with the sniff test in 44 patients with parietal infiltration of ropivacaine and in 44 patients with placebo. Our secondary outcomes are the evaluation of the effect of continuous parietal analgesia with ropivacaine on IPmax and EPmax, oxygen saturation, post operative pulmonary complications and post operative recovery. This prospective study will determine if the pre peritoneal local infiltration of ropivacaine is useful to decrease post operative diaphragmatic dysfunction.
Official title: Efficacy of Parietal Continuous Infiltration of Local Anesthesic on Diaphragmatic Function After Upper Abdominal Surgery Through a Subcostal Incision
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
31
Start Date
2014-07
Completion Date
2017-06
Last Updated
2026-04-29
Healthy Volunteers
No
Conditions
Interventions
Sniff test
Evaluation of diaphragmatic function by sniff test after continuous parietal infusion of ropivacaine or placebo
Infusion of Ropivacaine during 48 hours
20 ml Bolus (7,5 mg/ml) then continuous administration of 10 ml per hour (2 mg/ml) during 48 hours of Ropivacaine. 20 ml Bolus (NaCl 0.9 %) then continuous administration of 10 ml per hour, during 48 hours of NaCl 0.9 %.
Continuous parietal infusion with parietal catheter
Continuous parietal infiltration of Ropivacaine or placebo
Infusion of placebo during 48 hours
NaCl
Locations (1)
Rouen University Hospital
Rouen, France