Clinical Research Directory

Inclusion Criteria: * The subjects will be male and female patients with acute ischemic stroke of the brain. Vascular risk factors, including diabetes, hypertension, and coronary artery disease, are expected to be common, and will be recorded in the Source Documents (appendix). Patients will be included if: * Aged ≥ 18 years of age * Neuroimaging or clinical symptoms are consistent with an acute ischemic stroke (AIS) * There are no alternative explanations for symptoms (eg. tumor, witnessed seizure, history of complicated migraine headache, hypoglycemia \[blood sugar (BS) \< 50 mg/dL\] or hyperglycemia (BS \> 400 mg/dL) * Subject is able to be enrolled and have blood samples drawn (Note: inability to provide a sample within 48 hours does not preclude inclusion if consent is provided after this time and patient can provide blood at subsequent time points (see Table) * Subject is able to provide informed consent for participation in this research study Exclusion Criteria: * • Other known severe/terminal illness which limits life expectancy to \< 90 days, sepsis, disseminated intravascular coagulopathy (DIC), infective endocarditis, metastatic cancer, or cerebral vasculitis * Current diagnosis of or treatment for major depressive disorder * Women who are pregnant at the time of stroke, since pregnancy alters inflammatory markers * Communication problems due to aphasia at visit 2, inability to speak English * History of substance abuse and other relevant psychiatric conditions * Autoimmune, current or recent infection, hematological disorders, use of immune modulating drugs