Clinical Research Directory

Inclusion Criteria * Males and females * Stage III pressure ulcers measuring 5 cc - 36 cc in volume (as measured by filling the wound with Normal Saline). * Inpatient or outpatient treatment of pressure ulcers * Diabetic Foot Ulcer Stage 1 or 2 of any size * Co-morbidities may include: * Peripheral Vascular Disease (PVD) * Coronary Artery Disease (CAD) * Chronic Renal Disease (CRD) * Chronic Liver Disease (CLD) * Hypertension (HTN) * Diabetes * The ability of subjects to give appropriate consent or have an appropriate representative available to do so * The ability of subjects to return for weekly wound assessments Exclusion Criteria * Patients with allergies to TISSEEL, Tegaderm, or silicon * Diabetics with poor glucose metabolic control (HbA1c \> 9) * Target wounds that are in close proximity to potential cancerous lesions * Patients who require Negative Pressure Wound Therapy (NPWT), limb amputation, or surgical intervention at the target wound at the time of screening * Wounds located on the face * Patients with Stage 5 or 6 Peripheral Vascular disease (specifically, wounds that are caused by peripheral vascular disease such as leg ulcers) * Wounds caused by diabetes mellitus (diabetic foot ulcers). * BMI of \<16 Clinical signs of critical colonization or local infection * Prolonged (\> 6 months) use of steroids * Patients on active regimen of chemotherapy * Patients receiving radiation in proximity of wound * Decompensated chronic liver disease