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Longitudinal Study of Intra-Uterine Growth Restriction
Sponsor: University of Colorado, Denver
Summary
The investigation will employ a longitudinal approach in which every fetus diagnosed to be SGA (Small for Gestational Age ) will be studied at frequent intervals with sophisticated imaging techniques to assess subtle physiologic changes in the brain, heart, and placenta over time. These findings will be correlated with neurological and cardiovascular function in the newborn and early childhood. This research initiative should yield diagnostic and therapeutic templates that will improve the quality of life of IUGR babies in addition to providing important information that will better inform current diagnostic practices.
Official title: Longitudinal Study of Intra-Uterine Growth Restriction (IUGR)
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2015-04
Completion Date
2027-12
Last Updated
2026-02-13
Healthy Volunteers
No
Interventions
Ultrasound
With 3-D and 4-D high-resolution color Doppler methods it is possible to map out the placental circulation, fetal circulation, fetal brain, and fetal cardiac function. Investigators will collect these data points prenatally.
MRI
Similar to the Ultrasound data, investigators will collect MRI images of the fetal brain and the placenta. MRI will allow investigators to collect more detailed images of both the fetal brain and placenta, and investigators will be utilizing this technique both prenatally and postnatally.
Blood collection
The maternal and cord blood will be collected for the processing of plasma and serum. There may be early biomarkers of IUGR in the maternal circulation that investigators can use to better determine the appropriate strategy for clinical management of care. Collection and subsequent analysis of molecular markers in the umbilical cord blood will be used to further confirm physiological dysfunction as detected by ultrasound and MRI techniques.
Neurological Function Assessment
Neurological development tests including a Bayley exam, Mullen exam, Developmental Profile-3, Child Behavior Checklist, and Pediatric Stroke Outcome Measure (PSOM) will be performed.
Placental Analysis
Placentas will undergo pathological evaluation for placental function.
Measurement of body fat
The baby's body fat will be measured in a special incubator called a PEAPOD or BODPOD when an infant.
Pediatric heart ultrasound
Children will have ultrasounds of their hearts during follow-up visits.
Locations (1)
University of Colorado Denver Anschutz Medical Campus
Aurora, Colorado, United States