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Effect Of The System In The Enriched Fat Metabolism Of The Child Reached Mitochondrial Cytopathy
Sponsor: University Hospital, Lille
Summary
The aim of the present study is to compare Resting Energy Expenditure (REE) between normal fat diet (NFD) as a control vs high fat diet (HFD) as a treatment in Mitochondrial cytopathies disorders ( MID's ) patients. Secondary objectives is to compare diet induced thermogenesis (DIT) and body composition between NFD vs HFD. This study is a randomized cross-over study. Normal fat diet (ie 10 % proteins, 45 % lipids, 45 % carbohydrates) is the imposed diet at baseline, high fat diet (ie 10 % proteins, 30 % lipids, 60 % carbohydrates is used according to the cross-over design trial. Main evaluation criteria is REE and second evaluation criteria is DIT both measured by indirect calorimetry ). 36 included MID subjects will be included in this study. Main evaluation criteria and second evaluation criteria will be measured at baseline, 1 month, 2 month and 3 month.
Key Details
Gender
All
Age Range
5 Years - 21 Years
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2004-02
Completion Date
2009-12
Last Updated
2026-04-22
Healthy Volunteers
No
Conditions
Interventions
high fat diet
high fat diet as 10 % proteins, 30 % lipids, 60 % carbohydrates
normal fat diet
high fat diet as 10 % proteins, 45 % lipids,45 % carbohydrates
Locations (2)
Centre d'Investigation Clinique
Lille, France
Centre d'Investigation Clinique
Paris, France