Clinical Research Directory

Inclusion Criteria: * patients over 18 yo * patients undergoing major surgery of the upper limb * patients able to give their consent to follow the protocol of treatment and monitoring. Exclusion Criteria: * children, * patients under guardianship, * pregnant or lactating women, * patients with hemochromatosis, * allergy or known hypersensitivity to one of the molecules of treatment, * patients suffering or having already suffered from complex regional pain syndrome type 1 or type 2, * patients unable due to personal or professional mobility, to conduct post-operative follow up, * patients undergoing surgery with nerve suture with nerve graft, emergency surgery, * patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, * patients with chronic kidney disease