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BNHL-2015 for Children or Adolescents in China
Sponsor: Children's Cancer Group, China
Summary
The purpose of this study is to test whether adding 4 injections of rituximab and increasing the intensity of chemotherapy regimens in advanced patients can improve the EFS compared with the historical study CCCG-NHL-2010.
Official title: Treatment Regimen or Children or Adolescent With Mature B-cell NHL or B-AL in China
Key Details
Gender
All
Age Range
Any - 16 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2015-01-01
Completion Date
2029-12
Last Updated
2026-03-19
Healthy Volunteers
No
Conditions
Interventions
Prednisone,Vincristine, Cyclophosphamide
Prednisone 45mg/m2, D1\~7; Vincristine 1.5mg/m2(MAX 2mg), D1; Cyclophosphamide 300mg/m2, D1; Intrathecal injection, D1;
Cyclophosphamide, Vincristine, Cytarabine, Doxorubincin, Prednisone
Cyclophosphamide 800mg/m2, D1, then 200mg/m2, D2\~4;Vincristine 1.5mg/m2 (MAX 2mg), D1; Cytarabine 1g/m2/dose, (2 doses, 12-hour interval), D4;Doxorubincin 20mg/m2, D2,3; Prednisone 60mg/m2, D1\~7;Intrathecal injection, D1,8;
Ifosphamide, Etoposide, Methotrexate, Vincristine, Prednisone
Ifosphamide 1.2g/m2, D1\~5; Etoposide, 60mg/m2, D3\~5; Methotrexate, 0.5g/m2, D1;Vincristine 1.5mg/m2 (MAX 2mg), D1; Prednisone 60mg/m2, D1\~7;Intrathecal injection, D1;
Cyclophosphamide, Vindelsine, Cytarabine, Doxorubincin, Prednisone
Cyclophosphamide 800mg/m2, D1, then 200mg/m2, D2\~4;Vindelsine 3mg/m2 (MAX 5mg), D1; Cytarabine 2g/m2/dose, (2 doses, 12-hour interval), D4;Doxorubincin 20mg/m2, D2,3; Prednisone 60mg/m2, D1\~7;Intrathecal injection, D1,8;
Ifosphamide, Etoposide, Methotrexate, Vindelsine, Prednisone
Ifosphamide 1.2g/m2, D1\~5; Etoposide, 100mg/m2, D3\~5; Methotrexate, 5g/m2, D1;Vindelsine 3mg/m2 (MAX 5mg), D1; Prednisone 60mg/m2, D1\~7;Intrathecal injection, D1,8;
Rituximab
375mg/m2, 4 injections for patients in Risk group4; D0 of Protocol AA or BB;
Locations (1)
West China Second University Hospital of Sichuan University
Chengdu, Sichuan, China