Clinical Research Directory

Inclusion Criteria: * NAFLD diagnosis based on evidence of hepatic steatosis, either by imaging (using MRI) or by histology. * BMI ≥ 30 kg/m2 * Between 18 - 65 years of age Exclusion Criteria: * Incompetent to understand and/or sign the informed consent. * Causes for secondary hepatic fat accumulation such as significant alcohol consumption, medications, Wilson's disease, viral infections, starvation or parenteral nutrition, among others, and conditions associated with microvesicular steatosis * Ethanol consumption exceeding more than 14 standard beverages per week for males and more than 7 standard beverages per week for female. * Not able or willing to undergo MRI (for example claustrophobia, ICD, pacemaker). * Not willing to be informed about unexpected findings by MRI * Unwilling to collect bio samples. * Pregnancy and breastfeeding. * Indication or planned for bariatric surgery within one year after inclusion or a history of bariatric surgery. * Diagnosis of liver cirrhosis and/or hepatocellular carcinoma. * Current diagnosis of extrahepatic malignancy(s) or prior diagnosis within last 5 years. * Individuals about to undergo or recovering from a surgical or otherwise medical procedure that will interfere with data collection and analyses planned within the current cohort, will initially be excluded from participation, but are offered the opportunity to participate at a later moment in time