Clinical Research Directory

Inclusion Criteria: 1. Healthy female subjects 18-65 years of age with at least a 5 on the CSS scale on both outer thighs. 2. All subjects must have the affected areas that show the mattress phenomenon spontaneously when standing or while both lying and standing (Stage 2 or 3 of Nurnberger-Muller grading scale of cellulite7). 3. Subjects who are willing and have the ability to understand and provide informed consent for participation in the study and are able to communicate with the investigator. Exclusion Criteria: 1. Subjects who are pregnant or lactating. 2. Subjects who are unable to understand the protocol or to give informed consent. 3. Subjects currently under treatment with an antiplatelet or anticoagulant for any medical problem or patients who have coagulation disorder. 4. Subjects who have a known history of cold-induced disease such as cryoglobulinemia, paroxysmal cold hemoglobulinuria, cold urticaria. 5. Subjects who have active skin disease or skin infection in the treatment area. 6. Subjects who are allergic to lidocaine or prilocaine. 7. Subjects who are allergic to both cephalexin (or penicillin) AND levofloxacin (or another quinolone antibiotic). 8. Subjects who have history of abnormal scarring.