Clinical Research Directory
Browse clinical research sites, groups, and studies.
SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System
Sponsor: Medtronic Vascular
Summary
The purpose of this study is to test the hypothesis that renal denervation decreases blood pressure and is safe when studied in the presence of up to three standard antihypertensive medications.
Official title: Global Clinical Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System in Patients With Uncontrolled Hypertension on Standard Medical Therapy (SPYRAL HTN-ON MED)
Key Details
Gender
All
Age Range
20 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
337
Start Date
2015-07-22
Completion Date
2025-08-14
Last Updated
2026-06-11
Healthy Volunteers
No
Interventions
Symplicity Spyral™ multi-electrode renal denervation system
After a renal angiography according to standard procedures, subjects remain blinded and are immediately treated with the renal denervation procedure after randomization.
Sham Procedure
After a renal angiography according to standard procedures, subjects remain blinded and remain on the catheterization lab table for at least 20 minutes prior to introducer sheath removal.
Locations (56)
Heart Center Research, LLC
Huntsville, Alabama, United States
Stanford Hospital and Clinics
Stanford, California, United States
Yale New Haven Hospital
New Haven, Connecticut, United States
Washington DC VA Medical Center
Washington D.C., District of Columbia, United States
Baptist Medical Center Jacksonville
Jacksonville, Florida, United States
Memorial Hospital Jacksonville
Jacksonville, Florida, United States
Tallahassee Research Institute
Tallahassee, Florida, United States
Emory University Hospital Midtown
Atlanta, Georgia, United States
Piedmont Heart Institute
Atlanta, Georgia, United States
Iowa Heart Center
West Des Moines, Iowa, United States
University of Kentucky
Lexington, Kentucky, United States
St Joseph Mercy Oakland
Pontiac, Michigan, United States
Providence Hospital
Southfield, Michigan, United States
Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, United States
Hattiesburg Clinic
Hattiesburg, Mississippi, United States
Cardiology Associates Research LLC
Tupelo, Mississippi, United States
Barnes-Jewish Hospital
St Louis, Missouri, United States
Saint Barnabas Medical Center
Livingston, New Jersey, United States
North Shore University Hospital
Manhasset, New York, United States
Weill Cornell Medical College/The New York Presbyterian Hospital
New York, New York, United States
Mount Sinai Medical Center
New York, New York, United States
Duke University Medical Center
Durham, North Carolina, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
Oregon Health & Science University Hospital
Portland, Oregon, United States
PinnacleHealth Cardiovascular Institute
Harrisburg, Pennsylvania, United States
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
The Miriam Hospital
Providence, Rhode Island, United States
AnMed Health
Anderson, South Carolina, United States
Centennial Medical Center
Nashville, Tennessee, United States
Baylor Heart & Vascular Hospital
Dallas, Texas, United States
Charleston Area Medical Center
Charleston, West Virginia, United States
Aurora St. Luke's Medical Center
Milwaukee, Wisconsin, United States
Alfred Hospital
Melbourne, Victoria, Australia
St. George Hospital
Kogarah, Australia
Royal Perth
Perth, Australia
Klinikum Wels-Grieskirchen
Wels, Austria
Hamilton Heath
Hamilton, Ontario, Canada
St. Michael's Hospital
Toronto, Ontario, Canada
Clinique Pasteur
Toulouse, France
Universitäts-Herzzentrum Freiburg - Bad Krozingen GmbH
Bad Krozingen, Germany
Universitätsklinikum Erlangen
Erlangen, Germany
Universitätsklinikum des Saarlandes
Homburg, Germany
Herzzentrum Leipzig, Universitätsklinik
Leipzig, Germany
Sana Kliniken Lübeck
Lübeck, Germany
Hippokration General Hospital of Athens
Athens, Greece
University General Hospital of Thessaloniki (AHEPA)
Thessaloniki, Greece
Galway University Hospital
Galway, Ireland
Higashi Takarazuka Satoh Hospital
Takarazuka, Hyōgo, Japan
Shonan Kamakura General Hospital
Kamakura, Okamoto, Japan
Jichi Medical University Hospital
Shimotsuke, Tochigi, Japan
Mitsui Memorial Hospital
Chiyoda City, Tokyo, Japan
Saiseikai Nakatsu Hospital
Osaka, Japan
Royal Bournemouth Hospital
Bournemouth, United Kingdom
Cardiff and Vale University Health Board - University Hospital of Wales
Cardiff, United Kingdom
Royal Devon & Exeter NHS Foundation Trust
Exeter, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom