Clinical Research Directory

Inclusion Criteria: * Age between 5 and 21 years * Neurological diagnoses * Impairment of the upper extremity (for projects (i) and (ii) we might also include patients without upper extremity impairments to cover a wide range of patients with different abilities) * Other (non-neurological) diagnoses, who require intense training of the upper extremity Exclusion Criteria: * Strong adipositas, which makes it not possible to adjust the cuffs and orthoses to the anthropometrics of the participant * Fixed contractures of the upper extremity that should be positioned in ChARMin * Instabilities of bones or joints, fractures or osteoporosis/osteopenia * Allergy against material of cuffs * Open skin lesions of the upper extremity that should be positioned in ChARMin * Luxations or subluxations of joints of the upper extremity that should be positioned in ChARMin * Strong pain that increases while training in ChARMin\* * Injuries or lesioned nerves of the upper extremity that should be positioned in ChARMin\* * Strong spontaneous movements like ataxia, dyskinesia, myoclonus\* * Instable vital functions like pulmonal or cardiovascular conditions * Implanted pace maker, defibrillator of the heart * Implanted shunt by hydrocephalus\* * Implanted cochlear or baha\* * Uncooperative or aggressive behaviour * Known or suspected non-compliance * Severe cognitive deficits * Inability to signal pain or discomfort * Apraxia\* * Severe visual impairment (inability to see the screen) * Severe spasticity (Ashworth 4) * Severe epilepsy\* * Insufficient head stability * Infections requiring isolation of the patient Contraindications marked with an \* are relative contraindications. Final approval needs to be obtained from the medical doctor.