Clinical Research Directory

Inclusion Criteria: * Tumor Diagnosis: Low grade gliomas * Patients must be less than 21 years of age at study entry. * Central nervous system tumor. Patients with primary spinal cord lesions. Patients with metastatic disease are also allowed. * No previous therapy for the tumor with the exception of corticosteroids and surgery. * Performance status:Karnofsky Performance Scale (KPS for \> 16 yrs of age) or Lansky Performance Score (LPS for ≤ 16 years of age) ≥ 50 assessed within two weeks prior to registration * Seizure disorder should be well controlled. * Normal organ and marrow function * Female patients of childbearing potential must not be pregnant or breast-feeding. Female patients who have menstruated and are of childbearing potential must have a negative serum or urine pregnancy test prior to enrollment. * Patients of childbearing or child fathering potential must be willing to use a medically acceptable form of birth control, which includes abstinence, while being treated on this study and for 6 months after the last drug administration. * Ability of subject or parent/guardian to understand and the willingness to sign a written informed consent/assent document. Informed consent/assent must be signed prior to registration on this study. * Tissue blocks or slides must be sent. If tissue is unavailable, the study chair must be notified prior to enrollment. Exclusion Criteria: * Patients who are receiving any other investigational or chemotherapeutic agents will be excluded. * Patients with known inability to return for follow-up visits or obtain follow-up studies required to assess for toxicity to therapy. * Patients with Subepenydmal Giant Cell Astrocytomas are excluded. Patients with intrinsic brainstem tumors of the pons will be excluded from the study. * History of hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to platinum based chemotherapy. * Patients with uncontrolled inter-current illness are excluded. * Females who are pregnant or breast feeding are excluded.