Inclusion Criteria:
1. Between 6 weeks and 6 years of age on the day of study cord blood infusion.
2. MRI documented single arterial distribution infarction.
3. Initial injury occurring in the prenatal or perinatal period
4. Ability of child and caregiver to travel to Orlando, and stay for at least 4 days, and to return for all Follow-up visits (patient is responsible for cost of travel and lodging while in Orlando)
Exclusion Criteria:
1. Inability to obtain all pertinent medical records, including pertinent physician notes, laboratory findings, and radiographic images, related to the original injury, hospitalization and rehabilitation - must be sent to FHFC research team 14 days prior to scheduled study cord blood treatment. Need brain MRI with flair sequence \<2 weeks old.
2. Recent radiographic evidence (imaging performed within past 2 weeks) of extensive stroke as evidenced by \>100ml lesion
3. Multifocal infarctions on screening MRI.
4. Evidence of hypoxic-ischemic encephalopathy on screening MRI.
5. Uncorrected coagulopathy during the baseline period defined as INR \> 1.4; PTT\> 35 sec; PLT \< 100,000
6. Known history of:
1. Recently diagnosed infection (within past 2 weeks) requiring treatment and/or medical intervention
2. Renal disease or altered renal function as defined by serum creatinine \>1.5 mg/dL at admission
3. Hepatic disease or altered liver function as defined by SGPT \> 150 U/L, and/or T. Bilirubin \>1.3 mg/dL at enrollment
4. Malignancy
5. Immunosuppression as defined by WBC \< 3 (10x3) at admission
6. HIV
7. Any evidence of active maternal infection during the pregnancy (Hepatitis A, Hepatitis B, Hepatitis C, HIV 1, HIV 2, Human T-lymphotropic Virus (HTLV) 1, HTLV 2
8. Pneumonia, or chronic lung disease requiring oxygen
9. Cord blood sample contamination
10. Participation in a concurrent intervention study
11. Desire for organ-donation in the event of death
12. Unwillingness or inability to stay for at least four days following cord blood infusion (should any problems arise following the infusion) and to return for 6 month, and 1 year follow-up visits
