Clinical Research Directory

Inclusion Criteria: * Man or woman \> 18 years * Patients hospitalized at the palliative medical care unit of University Hospital Bordeaux * Patient whose life expectancy is greater to 4 weeks * Patients suffering from nausea the day of inclusion with a greater than or equal score to 3/10 on a numerical scale (FR) from 0 to 10 and / or have had at least one vomiting within three days prior to inclusion * Patients may be infused through an IV and subcutaneous (SC) * Patient can communicate verbally or in writing * Patients affiliates or beneficiaries of a social security fund * Patient has given his written consent Exclusion criteria * Pregnant or breastfeeding women * Current Treatment for severe and progressive threatening disease * Treatment with oral or injectable metoclopramide within 3 days prior to inclusion * Treatment with levodopa or dopamine agonists in progress * Neuroleptic Processing * Patient with lesion occlusive syndrome * Patients at risk of gastrointestinal perforation * Patient with clinical signs of gastrointestinal bleeding * Parkinson's disease * Patients with epilepsy not controlled by anti-seizure treatment * Patients suffering from liver failure * Patients with a heart rate less than 60 beats / min at baseline * Patients with systolic blood pressure less than or equal to 90 mmHg at baseline * History of allergy to metoclopramide * History of allergy to ondansetron * Previous history of tardive dyskinesia to neuroleptics or metoclopramide * Previous history of pheochromocytoma * Previous history of methemoglobinemia with metoclopramide * History of deficit NADH-cytochrome b5 reductase * Patient deprived of liberty by judicial or administrative decision * Major protected by law * Exclusion period Patient relative over another protocol. Exclusion criteria * Pregnant woman (blood β-HCG dosage ≥ 5 IU / L) * Patients with a creatinine clearance less than or equal to 60 mL / min at baseline * Patient with cardiac conduction disorders on ECG * Patients with electrolyte imbalance in electrolytes