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Stress Ulcer Prophylaxis in the Intensive Care Unit
Sponsor: Dr. Morten Hylander Møller
Summary
Stress ulcer prophylaxis (SUP) is standard of care in the intensive care unit (ICU), however the quantity and quality of evidence is low and potential harm has been reported. The aim of the SUP-ICU trial is to asses the overall benefits and harms of SUP with proton pump inhibitor in adult critically ill patients in the ICU.
Official title: Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3350
Start Date
2016-01
Completion Date
2018-01-21
Last Updated
2026-05-19
Healthy Volunteers
No
Conditions
Interventions
Pantoprazole
40 mg x 1 daily intravenously from ICU admission to ICU discharge
Saline (0.9%)
10 ml of isotonic saline x 1 daily intravenously from ICU admission to ICU discharge
Locations (33)
Dept. of Intensive Care, Aalborg University Hospital
Aalborg, Denmark
Dept. of Intensive Care, Århus University Hospital Nørrebrogade
Aarhus, Denmark
Dept. of Intensive Care, Århus University Hospital Skejby
Aarhus, Denmark
Dept. of Intensive Care 4131, Copenhagen University Hospital Rigshospitalet
Copenhagen, Denmark
Dept. of Neurointensive Care, Copenhagen University Hospital Rigshospitalet
Copenhagen, Denmark
Dept. of Intensive Care, Bispebjerg Hospital
Copenhagen, Denmark
Dept. of Intensive Care, Copenhagen University Hospital Herlev
Herlev, Denmark
Dept. of Intensive Care, Herning Hospital
Herning, Denmark
Dept. of Intensive Care, Hillerød Hospital
Hillerød, Denmark
Dept. of Intensive Care, Hjørring Hospital
Hjørring, Denmark
Dept. of Intensive Care, Holbæk Hospital
Holbæk, Denmark
Dept. of Intensive Care, Holstebro Hospital
Holstebro, Denmark
Dept. of Intensive Care, Køge University Hospital
Køge, Denmark
Dept. of Intensive Care, Nykøbing Falster Sygehus
Nykøbing Falster, Denmark
Dept. of Intensive Care, Randers Hospital
Randers, Denmark
Dept. of Intensive Care, Roskilde Hospital
Roskilde, Denmark
Dept. of Intensive Care, Slagelse Hospital
Slagelse, Denmark
Dept. of Intensive Care, Vejle Hospital
Vejle, Denmark
Dept. of Intensive Care, Viborg Hospital
Viborg, Denmark
Dept. of Intensive Care, Helsinki University Hospital
Helsinki, Finland
Dept. of Intensive Care, Kuopio University Hospital
Kuopio, Finland
Dept. of Intensive Care, Oulu University Hospital
Oulu, Finland
Dept. of Intensive Care, Tampere University Hospital
Tampere, Finland
Dept. of Intensive Care, Turku University Hospital
Turku, Finland
Dept. of Intensive Care, University Medical Center Groningen
Groningen, Netherlands
Dept. of Intensive Care, Heerlen Hospital
Heerlen, Netherlands
Dept. of Intensive Care, Bergen University Hospital
Bergen, Norway
Dept. of Intensive Care, Akershus University Hospital
Lørenskog, Norway
Dept. of Intensive Care, Oslo University Hospital
Oslo, Norway
Dept. of Intensive Care, Stavanger University Hospital
Stavanger, Norway
Dept. of Intensive Care, Basel University Hospital
Basel, Switzerland
Dept. of Intensive Care, Bern University Hospital
Bern, Switzerland
Dept. of Intensive Care, University Hospital of Wales
Cardiff, United Kingdom